2-{(8'-chloro-2'-oxo-2',3'-dihydro-1'H-spiro[cyclohexane-1,4'-quinazolin]-5'-yl)oxy}-3-fluorobenzecarboximidohydrazide

Base Information

Chemical Name:2-{(8'-chloro-2'-oxo-2',3'-dihydro-1'H-spiro[cyclohexane-1,4'-quinazolin]-5'-yl)oxy}-3-fluorobenzecarboximidohydrazide
CAS No.:1086424-70-5
Molecular Formula:C₂₀H₂₁ClFN₅O₂
Molecular Weight:417.87
Hs Code.:

Synonyms:2-{(8'-chloro-2'-oxo-2',3'-dihydro-1'H-spiro[cyclohexane-1,4'-quinazolin]-5'-yl)oxy}-3-fluorobenzecarboximidohydrazide

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Chemical Property of 2-{(8'-chloro-2'-oxo-2',3'-dihydro-1'H-spiro[cyclohexane-1,4'-quinazolin]-5'-yl)oxy}-3-fluorobenzecarboximidohydrazide

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Technology Process of 2-{(8'-chloro-2'-oxo-2',3'-dihydro-1'H-spiro[cyclohexane-1,4'-quinazolin]-5'-yl)oxy}-3-fluorobenzecarboximidohydrazide

There total 3 articles about 2-{(8'-chloro-2'-oxo-2',3'-dihydro-1'H-spiro[cyclohexane-1,4'-quinazolin]-5'-yl)oxy}-3-fluorobenzecarboximidohydrazide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

: 1086424-45-4
2-{(8'-chloro-2'-oxo-2',3'-dihydro-1'H-spiro[cyclohexane-1,4'-quinazolin]-5'-yl)oxy}-3-fluorobenzonitrile

: 1086424-70-5
2-{(8'-chloro-2'-oxo-2',3'-dihydro-1'H-spiro[cyclohexane-1,4'-quinazolin]-5'-yl)oxy}-3-fluorobenzecarboximidohydrazide

Guidance literature:: With phosphorous (V) sulfide; hydrazine; In N,N-dimethyl-formamide; at 70 ℃; for 24h;

Reference yield:

: 460346-10-5
8-chloro-5-hydroxy-spiro[1,3-dihydroquinazoline-4,1'-cyclohexane]-2-one

: 1086424-70-5
2-{(8'-chloro-2'-oxo-2',3'-dihydro-1'H-spiro[cyclohexane-1,4'-quinazolin]-5'-yl)oxy}-3-fluorobenzecarboximidohydrazide

Guidance literature:: Multi-step reaction with 2 steps

1: caesium carbonate / N,N-dimethyl-formamide / 20 h / 80 °C

2: phosphorous (V) sulfide; hydrazine / N,N-dimethyl-formamide / 24 h / 70 °C

With phosphorous (V) sulfide; caesium carbonate; hydrazine; In N,N-dimethyl-formamide;

Reference yield:

: 21524-39-0
2,3-difluorobenzonitrile

: 1086424-70-5
2-{(8'-chloro-2'-oxo-2',3'-dihydro-1'H-spiro[cyclohexane-1,4'-quinazolin]-5'-yl)oxy}-3-fluorobenzecarboximidohydrazide

Guidance literature:: Multi-step reaction with 2 steps

1: caesium carbonate / N,N-dimethyl-formamide / 20 h / 80 °C

2: phosphorous (V) sulfide; hydrazine / N,N-dimethyl-formamide / 24 h / 70 °C

With phosphorous (V) sulfide; caesium carbonate; hydrazine; In N,N-dimethyl-formamide;