Technology Process of 1-(3,4-dimethoxyphenyl)-3-hydroxy-5,6-dimethoxy-1,3-dihydrobenzothiophene 2,2-dioxide
There total 10 articles about 1-(3,4-dimethoxyphenyl)-3-hydroxy-5,6-dimethoxy-1,3-dihydrobenzothiophene 2,2-dioxide which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
sulfur dioxide;
In
thiophene;
for 8h;
Irradiation;
DOI:10.1021/jo00368a018
- Guidance literature:
-
Multi-step reaction with 4 steps
1: 1) n-BuLi / 1) THF, -78 deg C, 5 min, 2) THF, a) -78 deg C to room temperature, b) 17 h
2: 73 percent / trifluoroacetic acid, NaBH4 / acetic acid; CH2Cl2 / 0.1 h / 0 °C
3: 1) n-BuLi / 1) THF, -78 deg C, 1 min, 2) a) -78 deg C, 1 h, b) room temperature, 50 min
4: SO2, pyridine / benzene / 6 h / Irradiation
With
pyridine; sodium tetrahydroborate; n-butyllithium; sulfur dioxide; trifluoroacetic acid;
In
dichloromethane; acetic acid; benzene;
DOI:10.1021/jo00067a057
- Guidance literature:
-
Multi-step reaction with 5 steps
1: 80 percent / Br2, CH3COOH / 5 h / Ambient temperature
2: 98 percent / p-toluenosulfonic acid / benzene / 2 h / Heating
3: 1.) tetramethylene diamine, n-butyllithium, (n-Bu)3P*CuI / 1.) THF, hexane, -78 deg C, 2.) THF, hexane, from -78 deg C to RT, 0.5 h
4: 95 percent / 10percent aq. HCl / diethyl ether / 2 h / Ambient temperature
5: 67 percent / SO2 / thiophene / 8 h / Irradiation
With
hydrogenchloride; n-butyllithium; CuI*P(n-Bu)3; N,N,N,N,-tetramethylethylenediamine; sulfur dioxide; bromine; toluene-4-sulfonic acid; acetic acid;
In
thiophene; diethyl ether; benzene;
DOI:10.1021/jo00368a018
