5-chloro-2-[4-fluoro-2-(trifluoromethyl)phenyl]pentanoic acid

Base Information

• Chemical Name: 5-chloro-2-[4-fluoro-2-(trifluoromethyl)phenyl]pentanoic acid
• CAS No.: 1262107-27-6
• Molecular Formula: C₁₂H₁₁ClF₄O₂
• Molecular Weight: 298.665
• Mol file: 1262107-27-6.mol

Synonyms:5-chloro-2-[4-fluoro-2-(trifluoromethyl)phenyl]pentanoic acid

Chemical Property of 5-chloro-2-[4-fluoro-2-(trifluoromethyl)phenyl]pentanoic acid

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

Useful:

Technology Process of 5-chloro-2-[4-fluoro-2-(trifluoromethyl)phenyl]pentanoic acid

There total 1 articles about 5-chloro-2-[4-fluoro-2-(trifluoromethyl)phenyl]pentanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-(4-fluoro-2-(trifluoromethyl)phenyl)acetic acid (195447-80-4) + 1.3-chlorobromopropane (109-70-6) → 5-chloro-2-[4-fluoro-2-(trifluoromethyl)phenyl]pentanoic acid (1262107-27-6)

Guidance literature:

2-(4-fluoro-2-(trifluoromethyl)phenyl)acetic acid; With n-butyllithium; In tetrahydrofuran; hexane; at -78 ℃; for 0.25h; Inert atmosphere;

1.3-chlorobromopropane; In tetrahydrofuran; hexane; at 20 ℃;

Reference yield:

5-chloro-2-[4-fluoro-2-(trifluoromethyl)phenyl]pentanoic acid (1262107-27-6) + 3-methoxy-4-(2-methyl-1,3-oxazol-5-yl)benzohydrazide hydrochloride (1262106-83-1) → 2-{4-chloro-1-[4-fluoro-2-(trifluoromethyl)phenyl]butyl}-5-[3-methoxy-4-(2-methyl-1,3-oxazol-5-yl)phenyl]-1,3,4-oxadiazole (1262107-28-7)

Guidance literature:

5-chloro-2-[4-fluoro-2-(trifluoromethyl)phenyl]pentanoic acid; 3-methoxy-4-(2-methyl-1,3-oxazol-5-yl)benzohydrazide hydrochloride; With triethylamine; HATU; In N,N-dimethyl-formamide; at 0 ℃; for 1.5h;

With tetrachloromethane; triphenylphosphine; In acetonitrile; at 80 ℃; for 2h;

Reference yield:

5-chloro-2-[4-fluoro-2-(trifluoromethyl)phenyl]pentanoic acid (1262107-27-6) → (S)-8-[4-fluoro-2-(trifluoromethyl)phenyl]-3-[3-methoxy-4-(2-methyl-1,3-oxazol-5-yl)phenyl]-5,6,7,8-tetrahydro[1,2,4]triazolo[4,3-a]pyridine (1262106-57-9) + (R)-8-[4-fluoro-2-(trifluoromethyl)phenyl]-3-[3-methoxy-4-(2-methyl-1,3-oxazol-5-yl)phenyl]-5,6,7,8-tetrahydro[1,2,4]triazolo[4,3-a]pyridine (1262106-56-8)

Guidance literature:

Multi-step reaction with 3 steps

1.1: triethylamine; HATU / N,N-dimethyl-formamide / 1.5 h / 0 °C

1.2: 2 h / 80 °C

2.1: sodium azide / dimethyl sulfoxide / 3 h / 70 °C

2.2: 1 h / 60 °C

2.3: 1.5 h / 110 °C

3.1: CHIRALPAK AD / isopropyl alcohol; hexane / Resolution of racemate

With sodium azide; triethylamine; HATU; In hexane; dimethyl sulfoxide; N,N-dimethyl-formamide; isopropyl alcohol;

upstream raw materials:

2-(4-fluoro-2-(trifluoromethyl)phenyl)acetic acid

1.3-chlorobromopropane

Downstream raw materials:

2-{4-chloro-1-[4-fluoro-2-(trifluoromethyl)phenyl]butyl}-5-[3-methoxy-4-(2-methyl-1,3-oxazol-5-yl)phenyl]-1,3,4-oxadiazole

(S)-8-[4-fluoro-2-(trifluoromethyl)phenyl]-3-[3-methoxy-4-(2-methyl-1,3-oxazol-5-yl)phenyl]-5,6,7,8-tetrahydro[1,2,4]triazolo[4,3-a]pyridine

(R)-8-[4-fluoro-2-(trifluoromethyl)phenyl]-3-[3-methoxy-4-(2-methyl-1,3-oxazol-5-yl)phenyl]-5,6,7,8-tetrahydro[1,2,4]triazolo[4,3-a]pyridine