N-2,2-dimethoxyethyl α,β-dehydro-N-[N-(trifluoroacetyl)-1-phenylalanyl]-methylalaninamide

Base Information

• Chemical Name: N-2,2-dimethoxyethyl α,β-dehydro-N-[N-(trifluoroacetyl)-1-phenylalanyl]-methylalaninamide
• CAS No.: 446274-56-2
• Molecular Formula: C₁₉H₂₄F₃N₃O₅
• Molecular Weight: 431.412
• Mol file: 446274-56-2.mol

Synonyms:N-2,2-dimethoxyethyl α,β-dehydro-N-[N-(trifluoroacetyl)-1-phenylalanyl]-methylalaninamide

Chemical Property of N-2,2-dimethoxyethyl α,β-dehydro-N-[N-(trifluoroacetyl)-1-phenylalanyl]-methylalaninamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-2,2-dimethoxyethyl α,β-dehydro-N-[N-(trifluoroacetyl)-1-phenylalanyl]-methylalaninamide

There total 1 articles about N-2,2-dimethoxyethyl α,β-dehydro-N-[N-(trifluoroacetyl)-1-phenylalanyl]-methylalaninamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

2,2-dimethoxyethylamine (22483-09-6) + α,β-dehydro-N-[N-(trifluoroacetyl)-1-phenylalanyl]-methylalanine → N-2,2-dimethoxyethyl α,β-dehydro-N-[N-(trifluoroacetyl)-1-phenylalanyl]-methylalaninamide (446274-56-2)

Guidance literature:

With benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; triethylamine; In tetrahydrofuran; at 20 ℃; for 17h;

DOI:10.1016/S0040-4039(02)00462-8

Reference yield:

N-2,2-dimethoxyethyl α,β-dehydro-N-[N-(trifluoroacetyl)-1-phenylalanyl]-methylalaninamide (446274-56-2) → (Z)-2-[(S)-3-Phenyl-2-(2,2,2-trifluoro-acetylamino)-propionylamino]-but-2-enoic acid (2-oxo-ethyl)-amide

Guidance literature:

With trimethylsilyl iodide; In chloroform; at 50 ℃; for 8h;

DOI:10.1016/S0040-4039(02)00462-8

Reference yield:

N-2,2-dimethoxyethyl α,β-dehydro-N-[N-(trifluoroacetyl)-1-phenylalanyl]-methylalaninamide (446274-56-2) → 8-benzyl-2-ethyl-7H-imidazo[1,2-a]pyrazin-3-one; hydrochloride

Guidance literature:

Multi-step reaction with 2 steps

1.1: trimethylsilyl iodide / CHCl₃ / 8 h / 50 °C

2.1: K₂CO₃ / acetonitrile; H₂O / 4 h / Heating

2.2: aq. HCl / 20 °C

With trimethylsilyl iodide; potassium carbonate; In chloroform; water; acetonitrile;

DOI:10.1016/S0040-4039(02)00462-8

upstream raw materials:

2,2-dimethoxyethylamine