diphenylmethyl (2S,3R,5R)-3-methyl-4,4,7-trioxo-3-(thiosemicarbazono)methyl-4-thia-1-aza-bicyclo[3.2.0]heptane-2-carboxylate

Base Information

Chemical Name:diphenylmethyl (2S,3R,5R)-3-methyl-4,4,7-trioxo-3-(thiosemicarbazono)methyl-4-thia-1-aza-bicyclo[3.2.0]heptane-2-carboxylate
CAS No.:188250-38-6
Molecular Formula:C₂₂H₂₂N₄O₅S₂
Molecular Weight:486.572
Hs Code.:

Synonyms:diphenylmethyl (2S,3R,5R)-3-methyl-4,4,7-trioxo-3-(thiosemicarbazono)methyl-4-thia-1-aza-bicyclo[3.2.0]heptane-2-carboxylate

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Chemical Property of diphenylmethyl (2S,3R,5R)-3-methyl-4,4,7-trioxo-3-(thiosemicarbazono)methyl-4-thia-1-aza-bicyclo[3.2.0]heptane-2-carboxylate

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Technology Process of diphenylmethyl (2S,3R,5R)-3-methyl-4,4,7-trioxo-3-(thiosemicarbazono)methyl-4-thia-1-aza-bicyclo[3.2.0]heptane-2-carboxylate

There total 3 articles about diphenylmethyl (2S,3R,5R)-3-methyl-4,4,7-trioxo-3-(thiosemicarbazono)methyl-4-thia-1-aza-bicyclo[3.2.0]heptane-2-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 45.0%

: 188249-92-5
diphenylmethyl (2S,3R,5R)-3-formyl-3-methyl-4,4,7-trioxo-4-thia-1-aza-bicyclo[3.2.0]heptane-2-carboxylate

: 4346-94-5
thiosemicarbazide hydrochloride

: 188250-38-6
diphenylmethyl (2S,3R,5R)-3-methyl-4,4,7-trioxo-3-(thiosemicarbazono)methyl-4-thia-1-aza-bicyclo[3.2.0]heptane-2-carboxylate

Guidance literature:: With hydrogenchloride; In ethanol; dichloromethane; at 20 ℃;
DOI:10.1016/j.bmc.2005.02.020

Reference yield:

: 182750-65-8
benzhydryl 2β-hydroxymethyl-1,1-dioxopenicillanate

: 188250-38-6
diphenylmethyl (2S,3R,5R)-3-methyl-4,4,7-trioxo-3-(thiosemicarbazono)methyl-4-thia-1-aza-bicyclo[3.2.0]heptane-2-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: 76 percent / pyridinium chlorochromate / CH₂Cl₂ / 23 h / 20 °C

2: 45 percent / HCl / ethanol; CH₂Cl₂ / 20 °C

With hydrogenchloride; pyridinium chlorochromate; In ethanol; dichloromethane;
DOI:10.1016/j.bmc.2005.02.020

Reference yield:

: 182750-64-7
benzhydryl 2β-(chloroacetoxy)methyl-1,1-dioxo-penicillanate

: 188250-38-6
diphenylmethyl (2S,3R,5R)-3-methyl-4,4,7-trioxo-3-(thiosemicarbazono)methyl-4-thia-1-aza-bicyclo[3.2.0]heptane-2-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: thiourea / ethanol

2: 76 percent / pyridinium chlorochromate / CH₂Cl₂ / 23 h / 20 °C

3: 45 percent / HCl / ethanol; CH₂Cl₂ / 20 °C

With hydrogenchloride; thiourea; pyridinium chlorochromate; In ethanol; dichloromethane;
DOI:10.1016/j.bmc.2005.02.020