(4R,5S)-5-(tert-Butyl-diphenyl-silanyloxy)-4-methyl-2-oxo-piperidine-1-carboxylic acid tert-butyl ester

Base Information

Chemical Name:(4R,5S)-5-(tert-Butyl-diphenyl-silanyloxy)-4-methyl-2-oxo-piperidine-1-carboxylic acid tert-butyl ester
CAS No.:176966-79-3
Molecular Formula:C₂₇H₃₇NO₄Si
Molecular Weight:467.681
Hs Code.:

Synonyms:(4R,5S)-5-(tert-Butyl-diphenyl-silanyloxy)-4-methyl-2-oxo-piperidine-1-carboxylic acid tert-butyl ester

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Chemical Property of (4R,5S)-5-(tert-Butyl-diphenyl-silanyloxy)-4-methyl-2-oxo-piperidine-1-carboxylic acid tert-butyl ester

Chemical Property:

Purity/Quality:

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MSDS Files:: SDS file from LookChem

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Technology Process of (4R,5S)-5-(tert-Butyl-diphenyl-silanyloxy)-4-methyl-2-oxo-piperidine-1-carboxylic acid tert-butyl ester

There total 10 articles about (4R,5S)-5-(tert-Butyl-diphenyl-silanyloxy)-4-methyl-2-oxo-piperidine-1-carboxylic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 62.0%

: 176966-78-2
tert-butyl (5S)-5-(tert-butyldiphenylsilyloxy)-3,4-dehydro-piperidine-2-one-1-carboxylate

: 74-88-4
methyl iodide

: 176966-79-3
(4R,5S)-5-(tert-Butyl-diphenyl-silanyloxy)-4-methyl-2-oxo-piperidine-1-carboxylic acid tert-butyl ester

Guidance literature:: methyl iodide; With magnesium; In diethyl ether;

With copper(I) bromide dimethylsulfide complex; In diethyl ether; at -20 ℃; for 0.25h;

tert-butyl (5S)-5-(tert-butyldiphenylsilyloxy)-3,4-dehydro-piperidine-2-one-1-carboxylate; With chloro-trimethyl-silane; In diethyl ether; at 20 ℃; for 2h;
DOI:10.1016/j.tetlet.2013.07.042

Reference yield:

: 176966-80-6
tert-butyl (5S)-5-(tert-butyldiphenylsilyloxy)-4-methyl-2H-2-oxo-5,6-dihydro-piperidine-1-carboxylate

: 176966-79-3
(4R,5S)-5-(tert-Butyl-diphenyl-silanyloxy)-4-methyl-2-oxo-piperidine-1-carboxylic acid tert-butyl ester

: (4S,5S)-5-(tert-Butyl-diphenyl-silanyloxy)-4-methyl-2-oxo-piperidine-1-carboxylic acid tert-butyl ester

Guidance literature:: With hydrogen; palladium on activated charcoal; In ethyl acetate; for 12h; under 1500.1 Torr; Title compound not separated from byproducts; Ambient temperature;
DOI:10.1016/0957-4166(96)00085-7

Reference yield:

: (4S,5S)-5-(tert-Butyl-diphenyl-silanyloxy)-4-methyl-2-oxo-3-phenylselanyl-piperidine-1-carboxylic acid tert-butyl ester

: 176966-79-3
(4R,5S)-5-(tert-Butyl-diphenyl-silanyloxy)-4-methyl-2-oxo-piperidine-1-carboxylic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 30percent H₂O₂ / ethyl acetate / 0.75 h / Ambient temperature

2: H₂ / 10percent Pd/C / ethyl acetate / 12 h / 1500.1 Torr / Ambient temperature

With hydrogen; dihydrogen peroxide; palladium on activated charcoal; In ethyl acetate;
DOI:10.1016/0957-4166(96)00085-7