143866-70-0

Upstream product

• 231958-20-6 4-(4-chlorophenyl)-1,2,3,6-tetrahydro-1-(phenylmethyl)-pyridine 
• 56108-25-9 N-benzyl-4-(4-chlorophenyl)-4-hydroxypiperidin 
• 873-77-8 (4-chlorphenyl)magnesium bromide 
• 100-39-0 benzyl bromide 
• 41979-39-9 4-piperidone hydrochloride 
• 3612-20-2 1-phenylmethyl-4-piperidone 

Downstream Products

• 26905-02-2 4-(4-chlorophenyl)piperidine 

Relevant academic research and scientific papers

Pharmacophore-based discovery, synthesis, and biological evaluation of 4-phenyl-1-arylalkyl piperidines as dopamine transporter inhibitors

Pharmacophore-based discovery, synthesis, and structure-activity relationship (SAR) of a series of 4-phenyl-1-arylalkyl piperidines are disclosed. These compounds have been evaluated for their ability to inhibit reuptake of dopamine (DA) into striatal nerve endings (synaptosomes). The lead compound 5 and the most potent analogue 43 were found to have significant functional antagonism.

Piperidine derivatives

STR1 The invention provides piperidine derivatives of general formula (I) or an acid-addition salt thereof, in which R represents an optionally substituted alkyl, cycloalkyl, aryl or heterocyclyl group: R1 represents an optionally substituted alkyl, alkenyl, akynyl, cycloalkyl, aryl or heterocyclyl group; m represents an integer from 0 to 3; and each of R2 and R3 is independently selected from a group consisting of hydrogen atoms, alkyl and phenyl groups; with the proviso that R does not represent a 4-tert-butylphenyl group; processes for their preparation; compositions containing such compounds and their use as fungicides.