C₁₈H₁₈N₄O₂

Base Information

• Chemical Name: C₁₈H₁₈N₄O₂
• CAS No.: 1246519-54-9
• Molecular Formula: C₁₈H₁₈N₄O₂
• Molecular Weight: 322.367
• Mol file: 1246519-54-9.mol

Synonyms:C₁₈H₁₈N₄O₂

Chemical Property of C₁₈H₁₈N₄O₂

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₁₈H₁₈N₄O₂

There total 8 articles about C₁₈H₁₈N₄O₂ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C10H9N3O2 (1246520-83-1) + 2-methoxy-N-methylaniline (10541-78-3) → C18H18N4O2 (1246519-54-9)

Guidance literature:

C₁₀H₉N₃O₂; With N-chloro-succinimide; triphenylphosphine; In tetrahydrofuran; at 20 ℃; for 0.0833333h;

2-methoxy-N-methylaniline; With N,N-dimethyl-aniline; In tetrahydrofuran; at 20 ℃;

Reference yield:

2-chloro-3-carbaldehydepyridine (36404-88-3) → C18H18N4O2 (1246519-54-9)

Guidance literature:

Multi-step reaction with 8 steps

1.1: toluene-4-sulfonic acid; hydrazine hydrate / 21 h / 120 °C / Cooling with ice

2.1: potassium hydroxide; iodine / N,N-dimethyl-formamide / 1 h / 20 °C / Cooling with ice

3.1: sodium hydride / N,N-dimethyl-formamide / 3 h / Cooling with ice

3.2: 1 h / 20 °C / Cooling with ice

4.1: triethylamine / triphenylphosphine; palladium diacetate / 1,4-dioxane / 4 h / 100 °C / Inert atmosphere

5.1: sodium hydride / dimethyl sulfoxide / 2 h / 20 °C

5.2: 4 h / 20 °C

6.1: trifluoroacetic acid / 14 h / Reflux

7.1: sodium hydroxide; water / ethanol; tetrahydrofuran / 15 h / 20 °C

7.2: 20 °C / pH 3

8.1: N-chloro-succinimide; triphenylphosphine / tetrahydrofuran / 0.08 h / 20 °C

8.2: 20 °C

With N-chloro-succinimide; water; iodine; sodium hydride; toluene-4-sulfonic acid; hydrazine hydrate; triethylamine; triphenylphosphine; trifluoroacetic acid; potassium hydroxide; sodium hydroxide; palladium diacetate; triphenylphosphine; In tetrahydrofuran; 1,4-dioxane; ethanol; dimethyl sulfoxide; N,N-dimethyl-formamide;

Reference yield:

3-iodo-1H-pyrazolo[3,4-b]pyridine (117007-52-0) → C18H18N4O2 (1246519-54-9)

Guidance literature:

Multi-step reaction with 6 steps

1.1: sodium hydride / N,N-dimethyl-formamide / 3 h / Cooling with ice

1.2: 1 h / 20 °C / Cooling with ice

2.1: triethylamine / triphenylphosphine; palladium diacetate / 1,4-dioxane / 4 h / 100 °C / Inert atmosphere

3.1: sodium hydride / dimethyl sulfoxide / 2 h / 20 °C

3.2: 4 h / 20 °C

4.1: trifluoroacetic acid / 14 h / Reflux

5.1: sodium hydroxide; water / ethanol; tetrahydrofuran / 15 h / 20 °C

5.2: 20 °C / pH 3

6.1: N-chloro-succinimide; triphenylphosphine / tetrahydrofuran / 0.08 h / 20 °C

6.2: 20 °C

With N-chloro-succinimide; water; sodium hydride; triethylamine; triphenylphosphine; trifluoroacetic acid; sodium hydroxide; palladium diacetate; triphenylphosphine; In tetrahydrofuran; 1,4-dioxane; ethanol; dimethyl sulfoxide; N,N-dimethyl-formamide;

upstream raw materials:

C₁₀H₉N₃O₂

2-methoxy-N-methylaniline

2-chloro-3-carbaldehydepyridine

3-iodo-1H-pyrazolo[3,4-b]pyridine