(R)-6-(2-fluorophenyl)-4-(1H-indol-3-ylmethyl)-N,N-dimethyl-4H-<1,2,4>triazolo<4,3-a><1,4>benzodiazepine-1-methanamide

Base Information

Chemical Name:(R)-6-(2-fluorophenyl)-4-(1H-indol-3-ylmethyl)-N,N-dimethyl-4H-<1,2,4>triazolo<4,3-a><1,4>benzodiazepine-1-methanamide
CAS No.:103195-60-4
Molecular Formula:C₂₈H₂₅FN₆
Molecular Weight:464.545
Hs Code.:

Synonyms:(R)-6-(2-fluorophenyl)-4-(1H-indol-3-ylmethyl)-N,N-dimethyl-4H-<1,2,4>triazolo<4,3-a><1,4>benzodiazepine-1-methanamide

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Chemical Property of (R)-6-(2-fluorophenyl)-4-(1H-indol-3-ylmethyl)-N,N-dimethyl-4H-<1,2,4>triazolo<4,3-a><1,4>benzodiazepine-1-methanamide

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Technology Process of (R)-6-(2-fluorophenyl)-4-(1H-indol-3-ylmethyl)-N,N-dimethyl-4H-<1,2,4>triazolo<4,3-a><1,4>benzodiazepine-1-methanamide

There total 5 articles about (R)-6-(2-fluorophenyl)-4-(1H-indol-3-ylmethyl)-N,N-dimethyl-4H-<1,2,4>triazolo<4,3-a><1,4>benzodiazepine-1-methanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 35.0%

: 30354-18-8
N,N-dimethyl(methylene)ammonium chloride

: 103195-59-1
(R)-6-(2-fluorophenyl)-4-(1H-indol-3-ylmethyl)-4H-<1,2,4>triazolo<4,3-a><1,4>benzodiazepine

: 103195-60-4
(R)-6-(2-fluorophenyl)-4-(1H-indol-3-ylmethyl)-N,N-dimethyl-4H-<1,2,4>triazolo<4,3-a><1,4>benzodiazepine-1-methanamide

Guidance literature:: In N,N-dimethyl-formamide; at 80 ℃; for 3h;
DOI:10.1021/jm00396a028

Reference yield:

: 102671-69-2
(R)-5-(2-fluorophenyl)-1,3-dihydro-3-(1H-indol-3-ylmethyl)-2H-1,4-benzodiazepine-2-thione

: 103195-60-4
(R)-6-(2-fluorophenyl)-4-(1H-indol-3-ylmethyl)-N,N-dimethyl-4H-<1,2,4>triazolo<4,3-a><1,4>benzodiazepine-1-methanamide

Guidance literature:: Multi-step reaction with 3 steps

1: 1.4 g / NH₂NH₂ / methanol / 2.5 h / Ambient temperature

2: 47 percent / H₂SO₄ / ethanol / 10 h / Ambient temperature

3: 35 percent / dimethylformamide / 3 h / 80 °C

With sulfuric acid; hydrazine; In methanol; ethanol; N,N-dimethyl-formamide;
DOI:10.1021/jm00396a028

Reference yield:

: 102671-70-5
(R)-5-(2-fluorophenyl)-1,3-dihydro-3-(1H-indol-3-ylmethyl)-2H-1,4-benzodiazepin-2-one

: 103195-60-4
(R)-6-(2-fluorophenyl)-4-(1H-indol-3-ylmethyl)-N,N-dimethyl-4H-<1,2,4>triazolo<4,3-a><1,4>benzodiazepine-1-methanamide

Guidance literature:: Multi-step reaction with 4 steps

1: 65 percent / Lawesson's reagent / toluene / 1.5 h / Heating

2: 1.4 g / NH₂NH₂ / methanol / 2.5 h / Ambient temperature

3: 47 percent / H₂SO₄ / ethanol / 10 h / Ambient temperature

4: 35 percent / dimethylformamide / 3 h / 80 °C

With Lawessons reagent; sulfuric acid; hydrazine; In methanol; ethanol; N,N-dimethyl-formamide; toluene;
DOI:10.1021/jm00396a028