8-chloro-6-(2-fluorophenyl)-1-methyl-3-(methylthio)-4H-imidazo<1,5-a><1,4>benzodiazepine

Base Information

Chemical Name:8-chloro-6-(2-fluorophenyl)-1-methyl-3-(methylthio)-4H-imidazo<1,5-a><1,4>benzodiazepine
CAS No.:87120-66-9
Molecular Formula:C₁₉H₁₅ClFN₃S
Molecular Weight:371.866
Hs Code.:

Synonyms:8-chloro-6-(2-fluorophenyl)-1-methyl-3-(methylthio)-4H-imidazo<1,5-a><1,4>benzodiazepine

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Chemical Property of 8-chloro-6-(2-fluorophenyl)-1-methyl-3-(methylthio)-4H-imidazo<1,5-a><1,4>benzodiazepine

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Technology Process of 8-chloro-6-(2-fluorophenyl)-1-methyl-3-(methylthio)-4H-imidazo<1,5-a><1,4>benzodiazepine

There total 5 articles about 8-chloro-6-(2-fluorophenyl)-1-methyl-3-(methylthio)-4H-imidazo<1,5-a><1,4>benzodiazepine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 69.0%

: 87120-67-0
8-chloro-6-(2-fluorophenyl)-1-methyl-3-(methylthio)-4H-imidazo<1,5-a><1,4>benzodiazepine 5-oxide

: 87120-66-9
8-chloro-6-(2-fluorophenyl)-1-methyl-3-(methylthio)-4H-imidazo<1,5-a><1,4>benzodiazepine

Guidance literature:: With phosphorus trichloride; In dichloromethane; for 4h; Ambient temperature;
DOI:10.1002/jhet.5570200313

Reference yield:

: 87120-56-7
7-chloro-5-(2-fluorophenyl)-N-hydroxy-3H-1,4-benzodiazepine-2-carboximidothioic acid methyl ester 4-oxide

: 87120-66-9
8-chloro-6-(2-fluorophenyl)-1-methyl-3-(methylthio)-4H-imidazo<1,5-a><1,4>benzodiazepine

Guidance literature:: Multi-step reaction with 3 steps

1: 90 percent / NaBH₄ / ethanol; tetrahydrofuran / 2 h / Ambient temperature

2: 73 percent / acetic acid / 1 h / 100 °C

3: 69 percent / PCl₃ / CH₂Cl₂ / 4 h / Ambient temperature

With sodium tetrahydroborate; phosphorus trichloride; In tetrahydrofuran; ethanol; dichloromethane; acetic acid;
DOI:10.1002/jhet.5570200313

Reference yield:

: 87120-59-0
7-chloro-5-(2-fluorophenyl)-2,3-dihydro-N-hydroxy-1H-1,4-benzodiazepine-2-carboximidothioic acid methyl ester 4-oxide

: 87120-66-9
8-chloro-6-(2-fluorophenyl)-1-methyl-3-(methylthio)-4H-imidazo<1,5-a><1,4>benzodiazepine

Guidance literature:: Multi-step reaction with 2 steps

1: 73 percent / acetic acid / 1 h / 100 °C

2: 69 percent / PCl₃ / CH₂Cl₂ / 4 h / Ambient temperature

With phosphorus trichloride; In dichloromethane; acetic acid;
DOI:10.1002/jhet.5570200313