Technology Process of bisebromoamide
There total 33 articles about bisebromoamide which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
2,3,4-lutidine; 1-hydroxy-7-aza-benzotriazole; HATU;
In
N,N-dimethyl-formamide;
at 0 - 20 ℃;
for 16h;
DOI:10.1021/ol101021v
- Guidance literature:
-
With
sodium hydrogencarbonate;
In
methanol;
at 70 ℃;
for 24h;
pH=6;
aq. buffer;
Inert atmosphere;
DOI:10.1016/j.tetlet.2010.11.058
- Guidance literature:
-
Multi-step reaction with 8 steps
1: diethylamine / acetonitrile / 1 h / 20 °C
2: N-ethyl-N,N-diisopropylamine; HATU / dichloromethane / 0 °C
3: tetrakis(triphenylphosphine) palladium(0); N-methylaniline / tetrahydrofuran / 0.5 h / 20 °C
4: 1-hydroxy-7-aza-benzotriazole; N-ethyl-N,N-diisopropylamine; HATU / dichloromethane / 0 °C
5: diethylamine / acetonitrile / 1 h / 20 °C
6: N-ethyl-N,N-diisopropylamine; HATU / dichloromethane; N,N-dimethyl-formamide / 0 °C
7: dichloromethane / 4 h / 20 °C
8: sodium hydrogencarbonate / methanol / 24 h / 70 °C / pH 6 / aq. buffer; Inert atmosphere
With
tetrakis(triphenylphosphine) palladium(0); 1-hydroxy-7-aza-benzotriazole; sodium hydrogencarbonate; diethylamine; N-ethyl-N,N-diisopropylamine; HATU; N-methylaniline;
In
tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1016/j.tetlet.2010.11.058