(6S)-4--7-phenyl-6-tosylamido-1-hepten-4-ol

Base Information

Chemical Name:(6S)-4--7-phenyl-6-tosylamido-1-hepten-4-ol
CAS No.:221467-91-0
Molecular Formula:C₂₈H₃₅NO₃SSi
Molecular Weight:493.742
Hs Code.:

(6S)-4-<dimethyl(phenyl)silyl>-7-phenyl-6-tosylamido-1-hepten-4-ol

Synonyms:(6S)-4--7-phenyl-6-tosylamido-1-hepten-4-ol

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Chemical Property of (6S)-4--7-phenyl-6-tosylamido-1-hepten-4-ol

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Technology Process of (6S)-4--7-phenyl-6-tosylamido-1-hepten-4-ol

There total 7 articles about (6S)-4--7-phenyl-6-tosylamido-1-hepten-4-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: 7393-43-3
tetraallyl tin

: 221467-77-2
(S)-(4-phenyl-3-tosylamidobutanoyl)dimethylphenylsilane

: 221467-91-0
(6S)-4--7-phenyl-6-tosylamido-1-hepten-4-ol

Guidance literature:: With scandium tris(trifluoromethanesulfonate); In dichloromethane;
DOI:10.1002/(SICI)1099-0690(199902)1999:2<437::AID-EJOC437>3.0.CO;2-V

Reference yield: 62.0%

: 221467-77-2
(S)-(4-phenyl-3-tosylamidobutanoyl)dimethylphenylsilane

: 762-72-1
allyl-trimethyl-silane

: 221467-91-0
(6S)-4--7-phenyl-6-tosylamido-1-hepten-4-ol

Guidance literature:: With titanium tetrachloride; In dichloromethane; at -78 ℃; for 24h;
DOI:10.1002/(SICI)1099-0690(199902)1999:2<437::AID-EJOC437>3.0.CO;2-V

Reference yield:

: 3182-95-4
L-Phenylalaninol

: 221467-91-0
(6S)-4--7-phenyl-6-tosylamido-1-hepten-4-ol

Guidance literature:: Multi-step reaction with 7 steps

1: 98 percent / tetrahydrofuran; H₂O / 9 h / Ambient temperature

2: 90 percent / triphenylphosphane, imidazole, iodine / acetonitrile / 2 h / 95 - 100 °C

3: 65 percent / acetonitrile / 4 h / 70 °C

4: 70 percent / glacial acetic acid, conc. H₂SO₄ / H₂O / 9 h / 110 °C

5: 95 percent / SOCl₂ / 6 h / 55 - 60 °C

6: 50 percent / tetrahydrofuran / 1 h / -78 °C

7: 96 percent / Sc(OTf)3 / CH₂Cl₂

With 1H-imidazole; thionyl chloride; sulfuric acid; iodine; acetic acid; triphenylphosphine; scandium tris(trifluoromethanesulfonate); In tetrahydrofuran; dichloromethane; water; acetonitrile;
DOI:10.1002/(SICI)1099-0690(199902)1999:2<437::AID-EJOC437>3.0.CO;2-V