Isoquinoline-5-sulfonic acid [2-(3-chloro-benzylamino)-ethyl]-amide; hydrochloride

Base Information

• Chemical Name: Isoquinoline-5-sulfonic acid [2-(3-chloro-benzylamino)-ethyl]-amide; hydrochloride
• CAS No.: 116970-59-3
• Molecular Formula: C₁₈H₁₈ClN₃O₂S*2ClH
• Molecular Weight: 448.801
• Mol file: 116970-59-3.mol

Synonyms:Isoquinoline-5-sulfonic acid [2-(3-chloro-benzylamino)-ethyl]-amide; hydrochloride

Chemical Property of Isoquinoline-5-sulfonic acid [2-(3-chloro-benzylamino)-ethyl]-amide; hydrochloride

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Isoquinoline-5-sulfonic acid [2-(3-chloro-benzylamino)-ethyl]-amide; hydrochloride

There total 3 articles about Isoquinoline-5-sulfonic acid [2-(3-chloro-benzylamino)-ethyl]-amide; hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 34.0%

N-(2-aminoethyl)-5-isoquinoline-sulphonamide hydrochloride (116970-50-4) + 1-Chloro-3-chloromethyl-benzene (620-20-2,130468-19-8) → Isoquinoline-5-sulfonic acid [2-(3-chloro-benzylamino)-ethyl]-amide; hydrochloride (116970-59-3)

Guidance literature:

With potassium carbonate; In tetrahydrofuran;

DOI:10.1021/jm00121a010

Reference yield:

isoquinoline-5-sulfonic acid (27655-40-9) → Isoquinoline-5-sulfonic acid [2-(3-chloro-benzylamino)-ethyl]-amide; hydrochloride (116970-59-3)

Guidance literature:

Multi-step reaction with 3 steps

1: 91 percent / SOCl₂, DMF / 2 h / Heating

2: 71 percent / NaHCO₃ / 1) H₂O, 2) CH₂Cl₂, RT, 1 h

3: 34 percent / K₂CO₃ / tetrahydrofuran

With thionyl chloride; sodium hydrogencarbonate; potassium carbonate; N,N-dimethyl-formamide; In tetrahydrofuran;

DOI:10.1021/jm00121a010

Reference yield:

isoquinoline-5-sulfonyl chloride hydrochloride (105627-79-0) → Isoquinoline-5-sulfonic acid [2-(3-chloro-benzylamino)-ethyl]-amide; hydrochloride (116970-59-3)

Guidance literature:

Multi-step reaction with 2 steps

1: 71 percent / NaHCO₃ / 1) H₂O, 2) CH₂Cl₂, RT, 1 h

2: 34 percent / K₂CO₃ / tetrahydrofuran

With sodium hydrogencarbonate; potassium carbonate; In tetrahydrofuran;

DOI:10.1021/jm00121a010

upstream raw materials:

N-(2-aminoethyl)-5-isoquinoline-sulphonamide hydrochloride

1-Chloro-3-chloromethyl-benzene

isoquinoline-5-sulfonic acid

isoquinoline-5-sulfonyl chloride hydrochloride