Technology Process of ((E)-(1R,6S,7R)-8-Benzyloxy-6-tert-butoxy-1-ethyl-7-methyl-oct-2-enyloxy)-tert-butyl-dimethyl-silane
There total 11 articles about ((E)-(1R,6S,7R)-8-Benzyloxy-6-tert-butoxy-1-ethyl-7-methyl-oct-2-enyloxy)-tert-butyl-dimethyl-silane which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 8 steps
1: 99 percent / CuI / diethyl ether
2: Amberlyst H-15 / hexane
3: 86 percent / OsO4, NaIO4 / dioxane; H2O
4: 96 percent / LiAlH4 / diethyl ether / -80 °C
5: 98 percent / pyridine
6: 64 percent / NaI, NaHCO3 / acetone
7: 86 percent / dimethylformamide / 20 °C
8: 1.) n-BuLi; 2.) BzCl; 3.) Na-Hg / 1.) THF, -80 deg C; 2.) -80 deg C to 0 deg C; 3.) THF, MeOH
With
pyridine; sodium periodate; osmium(VIII) oxide; lithium aluminium tetrahydride; n-butyllithium; sodium amalgam; Amberlyst H-15; sodium hydrogencarbonate; benzoyl chloride; sodium iodide;
copper(l) iodide;
In
1,4-dioxane; diethyl ether; hexane; water; N,N-dimethyl-formamide; acetone;
DOI:10.1055/s-1997-1547
- Guidance literature:
-
Multi-step reaction with 9 steps
1: 1.) 30percent HBr/AcOH; 2.) KOH / 1.) Et2O; 2.) MeOH, THF
2: 99 percent / CuI / diethyl ether
3: Amberlyst H-15 / hexane
4: 86 percent / OsO4, NaIO4 / dioxane; H2O
5: 96 percent / LiAlH4 / diethyl ether / -80 °C
6: 98 percent / pyridine
7: 64 percent / NaI, NaHCO3 / acetone
8: 86 percent / dimethylformamide / 20 °C
9: 1.) n-BuLi; 2.) BzCl; 3.) Na-Hg / 1.) THF, -80 deg C; 2.) -80 deg C to 0 deg C; 3.) THF, MeOH
With
pyridine; potassium hydroxide; sodium periodate; osmium(VIII) oxide; lithium aluminium tetrahydride; n-butyllithium; sodium amalgam; Amberlyst H-15; hydrogen bromide; sodium hydrogencarbonate; benzoyl chloride; acetic acid; sodium iodide;
copper(l) iodide;
In
1,4-dioxane; diethyl ether; hexane; water; N,N-dimethyl-formamide; acetone;
DOI:10.1055/s-1997-1547
- Guidance literature:
-
Multi-step reaction with 10 steps
1: 96 percent / TsOH / methanol
2: 1.) 30percent HBr/AcOH; 2.) KOH / 1.) Et2O; 2.) MeOH, THF
3: 99 percent / CuI / diethyl ether
4: Amberlyst H-15 / hexane
5: 86 percent / OsO4, NaIO4 / dioxane; H2O
6: 96 percent / LiAlH4 / diethyl ether / -80 °C
7: 98 percent / pyridine
8: 64 percent / NaI, NaHCO3 / acetone
9: 86 percent / dimethylformamide / 20 °C
10: 1.) n-BuLi; 2.) BzCl; 3.) Na-Hg / 1.) THF, -80 deg C; 2.) -80 deg C to 0 deg C; 3.) THF, MeOH
With
pyridine; potassium hydroxide; sodium periodate; osmium(VIII) oxide; lithium aluminium tetrahydride; n-butyllithium; sodium amalgam; Amberlyst H-15; hydrogen bromide; sodium hydrogencarbonate; benzoyl chloride; toluene-4-sulfonic acid; acetic acid; sodium iodide;
copper(l) iodide;
In
1,4-dioxane; methanol; diethyl ether; hexane; water; N,N-dimethyl-formamide; acetone;
DOI:10.1055/s-1997-1547
