3,5-bis(benzyloxy)-2-(3,4-bis(benzyloxy)phenyl)-7-hydroxy-4H-chromen-4-one

Base Information

• Chemical Name: 3,5-bis(benzyloxy)-2-(3,4-bis(benzyloxy)phenyl)-7-hydroxy-4H-chromen-4-one
• CAS No.: 1268621-72-2
• Molecular Formula: C₄₃H₃₄O₇
• Molecular Weight: 662.739
• Mol file: 1268621-72-2.mol

Synonyms:3,5-bis(benzyloxy)-2-(3,4-bis(benzyloxy)phenyl)-7-hydroxy-4H-chromen-4-one

Chemical Property of 3,5-bis(benzyloxy)-2-(3,4-bis(benzyloxy)phenyl)-7-hydroxy-4H-chromen-4-one

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3,5-bis(benzyloxy)-2-(3,4-bis(benzyloxy)phenyl)-7-hydroxy-4H-chromen-4-one

There total 4 articles about 3,5-bis(benzyloxy)-2-(3,4-bis(benzyloxy)phenyl)-7-hydroxy-4H-chromen-4-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

2-(3,4-dihydroxyphenyl)-3,5-dihydroxy-7-(methoxymethoxy)-4H-chromen-4-one + benzyl bromide (100-39-0) → 3,5-bis(benzyloxy)-2-(3,4-bis(benzyloxy)phenyl)-7-hydroxy-4H-chromen-4-one (1268621-72-2)

Guidance literature:

2-(3,4-dihydroxyphenyl)-3,5-dihydroxy-7-(methoxymethoxy)-4H-chromen-4-one; benzyl bromide; With potassium carbonate; In N,N-dimethyl-formamide; at 80 ℃; for 4h;

With hydrogenchloride; In water; N,N-dimethyl-formamide; at 40 ℃; for 4h;

DOI:10.1016/j.bmc.2016.12.034

Reference yield: 40.0%

2-[3,4-bis(phenylmethoxy)phenyl]-3,5,7-tris(phenylmethoxy)chromen-4-one (13157-90-9) → 3,5-bis(benzyloxy)-2-(3,4-bis(benzyloxy)phenyl)-7-hydroxy-4H-chromen-4-one (1268621-72-2)

Guidance literature:

With aluminum oxide; [bis(acetoxy)iodo]benzene; copper(II) bis(trifluoromethanesulfonate); toluene-4-sulfonamide; In dichloromethane; at 20 ℃; Inert atmosphere;

DOI:10.1055/s-0030-1258310

Reference yield:

acetic acid 2-acetoxy-4-(3,5-diacetoxy-7-hydroxy-4-oxo-4H-chromen-2-yl)-phenyl ester (143631-95-2) → 3,5-bis(benzyloxy)-2-(3,4-bis(benzyloxy)phenyl)-7-hydroxy-4H-chromen-4-one (1268621-72-2)

Guidance literature:

Multi-step reaction with 3 steps

1.1: potassium carbonate / acetone / 4 h / 20 °C

2.1: ammonia; methanol / 4 h / 0 °C

3.1: potassium carbonate / N,N-dimethyl-formamide / 4 h / 80 °C

3.2: 4 h / 40 °C

With methanol; ammonia; potassium carbonate; In N,N-dimethyl-formamide; acetone;

DOI:10.1016/j.bmc.2016.12.034

upstream raw materials:

2-[3,4-bis(phenylmethoxy)phenyl]-3,5,7-tris(phenylmethoxy)chromen-4-one

benzyl bromide

acetic acid 2-acetoxy-4-(3,5-diacetoxy-7-hydroxy-4-oxo-4H-chromen-2-yl)-phenyl ester

4-[3,5-diacetoxy-7-(methoxymethoxy)-4-oxo-4H-chromen-2-yl]-1,2-phenylene diacetate