3-(2-(tetrahydro-2H-pyran-2-yl)oxyethyl)-6-methoxymethyl-2,4-dimethylbenzaldehyde

Base Information

Chemical Name:3-(2-(tetrahydro-2H-pyran-2-yl)oxyethyl)-6-methoxymethyl-2,4-dimethylbenzaldehyde
CAS No.:79801-60-8
Molecular Formula:C₁₈H₂₆O₄
Molecular Weight:306.402
Hs Code.:

Synonyms:3-(2-(tetrahydro-2H-pyran-2-yl)oxyethyl)-6-methoxymethyl-2,4-dimethylbenzaldehyde

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Chemical Property of 3-(2-(tetrahydro-2H-pyran-2-yl)oxyethyl)-6-methoxymethyl-2,4-dimethylbenzaldehyde

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Technology Process of 3-(2-(tetrahydro-2H-pyran-2-yl)oxyethyl)-6-methoxymethyl-2,4-dimethylbenzaldehyde

There total 5 articles about 3-(2-(tetrahydro-2H-pyran-2-yl)oxyethyl)-6-methoxymethyl-2,4-dimethylbenzaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 3-(2-(tetrahydro-2H-pyran-2-yl)oxyethyl)-6-methoxymethyl-2,4-dimethylbenzyl alcohol

: 79801-60-8
3-(2-(tetrahydro-2H-pyran-2-yl)oxyethyl)-6-methoxymethyl-2,4-dimethylbenzaldehyde

Guidance literature:: With sodium acetate; pyridinium chlorochromate; In dichloromethane; for 1h; Ambient temperature;
DOI:10.1139/v81-311

Reference yield:

: 74973-56-1
2-(4-methoxymethyl-2,6-dimethylphenyl)ethanol

: 79801-60-8
3-(2-(tetrahydro-2H-pyran-2-yl)oxyethyl)-6-methoxymethyl-2,4-dimethylbenzaldehyde

Guidance literature:: Multi-step reaction with 5 steps

1: bromine / nitromethane / 0.5 h / 0 °C

2: 95 percent / pyridinium tosylate / CH₂Cl₂ / 1 h / Ambient temperature

3: 62 percent / 1.6 M n-butyllithium / tetrahydrofuran / 1.) -78 deg C, 50 min; 2.) 0 deg C, 16 h

4: 77 percent / LAH / diethyl ether / 2 h / Ambient temperature

5: 98 percent / pyridinium chlorochromate, sodium acetate / CH₂Cl₂ / 1 h / Ambient temperature

With lithium aluminium tetrahydride; n-butyllithium; bromine; sodium acetate; pyridinium p-toluenesulfonate; pyridinium chlorochromate; In tetrahydrofuran; diethyl ether; nitromethane; dichloromethane;
DOI:10.1139/v81-311

Reference yield:

: 79801-57-3
2-(3-bromo-4-methoxymethyl-2,6-dimethylphenyl)ethanol

: 79801-60-8
3-(2-(tetrahydro-2H-pyran-2-yl)oxyethyl)-6-methoxymethyl-2,4-dimethylbenzaldehyde

Guidance literature:: Multi-step reaction with 4 steps

1: 95 percent / pyridinium tosylate / CH₂Cl₂ / 1 h / Ambient temperature

2: 62 percent / 1.6 M n-butyllithium / tetrahydrofuran / 1.) -78 deg C, 50 min; 2.) 0 deg C, 16 h

3: 77 percent / LAH / diethyl ether / 2 h / Ambient temperature

4: 98 percent / pyridinium chlorochromate, sodium acetate / CH₂Cl₂ / 1 h / Ambient temperature

With lithium aluminium tetrahydride; n-butyllithium; sodium acetate; pyridinium p-toluenesulfonate; pyridinium chlorochromate; In tetrahydrofuran; diethyl ether; dichloromethane;
DOI:10.1139/v81-311