5-Chloro-2,8-dimethyl-4-quinolinol

Base Information

• Chemical Name: 5-Chloro-2,8-dimethyl-4-quinolinol
• CAS No.: 21629-50-5
• Molecular Formula: C₁₁H₁₀ClNO
• Molecular Weight: 207.659
• Hs Code.: 2933499090
• European Community (EC) Number: 667-438-8
• DSSTox Substance ID: DTXSID00383845
• Nikkaji Number: J307.748I
• Wikidata: Q82175644
• Mol file: 21629-50-5.mol

Synonyms:21629-50-5;5-CHLORO-2,8-DIMETHYL-4-QUINOLINOL;5-chloro-2,8-dimethylquinolin-4-ol;5-Chloro-2,8-dimethyl-4-hydroxyquinoline;5-chloro-2,8-dimethyl-1H-quinolin-4-one;4-Quinolinol,5-chloro-2,8-dimethyl-;MFCD00023980;Maybridge1_000304;Oprea1_127376;HMS542F18;DTXSID00383845;AKOS002358719;AKOS009096831;AB01397;CCG-234531;FT-0620237;5-CHLORO-4-HYDROXY-8-METHYLQUINALDINE;BRD-K13833020-001-01-8;F3284-7418

Chemical Property of 5-Chloro-2,8-dimethyl-4-quinolinol

Chemical Property:

• Vapor Pressure: 0.000155mmHg at 25°C
• Refractive Index: 1.579
• Boiling Point: 331.5°C at 760 mmHg
• PKA: 3.85±0.40(Predicted)
• Flash Point: 154.3°C
• PSA: 33.12000
• Density: 1.233g/cm³
• LogP: 3.21060
• XLogP3: 2.9
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 0
• Exact Mass: 207.0450916
• Heavy Atom Count: 14
• Complexity: 287

Purity/Quality:

98%Min ^*data from raw suppliers

5-chloro-2,8-dimethylquinolin-4-ol ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1=C2C(=C(C=C1)Cl)C(=O)C=C(N2)C

Technology Process of 5-Chloro-2,8-dimethyl-4-quinolinol

There total 3 articles about 5-Chloro-2,8-dimethyl-4-quinolinol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C13H16ClNO2 (216876-32-3) → 5-Chloro-2,8-dimethyl-quinolin-4-ol (21629-50-5)

Guidance literature:

In diphenylether; for 0.5h; Reflux;

DOI:10.1007/s00044-011-9854-3

Reference yield:

5-chloro-2-methyl-benzenamine (95-79-4) → 5-Chloro-2,8-dimethyl-quinolin-4-ol (21629-50-5)

Guidance literature:

Multi-step reaction with 2 steps

1: methanol / 7 h / 40 °C

2: diphenylether / 0.5 h / Reflux

In methanol; diphenylether;

DOI:10.1007/s00044-011-9854-3

Reference yield:

→ 5-Chloro-2,8-dimethyl-quinolin-4-ol (21629-50-5)

Guidance literature:

5-Chlor-2-methylanilin, Acetessigsaeure-ethylester;

upstream raw materials:

C₁₃H₁₆ClNO₂

5-chloro-2-methyl-benzenamine

Downstream raw materials:

4,5-dichloro-2,8-dimethyl-quinoline

Refernces