216876-32-3

Basic information

• Product Name: C₁₃H₁₆ClNO₂
• CAS NO: 216876-32-3
• Molecular Weight: 253.729
• Mol File: 216876-32-3.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₁₃H₁₆ClNO₂(CAS DataBase Reference)
• NIST Chemistry Reference: C₁₃H₁₆ClNO₂(216876-32-3)
• EPA Substance Registry System: C₁₃H₁₆ClNO₂(216876-32-3)

Safety Data

• Hazardous Substances Data: 216876-32-3(Hazardous Substances Data)

Upstream product

• 141-97-9 ethyl acetoacetate 
• 95-79-4 5-chloro-2-methyl-benzenamine 

Downstream Products

• 21629-50-5 5-Chloro-2,8-dimethyl-quinolin-4-ol 
• 21629-52-7 4,5-dichloro-2,8-dimethyl-quinoline 

Relevant articles and documents

N1-{4-[(10S)-Dihydroartemisinin-10-oxyl]}phenylmethylene-N 2-(2-methylquinoline-4-yl)hydrazine derivatives as antiplasmodial falcipain-2 inhibitors

A series of N1-{4-[(10S)-dihydroartemisinin- 10-oxyl]}phenylmethylene-N2-(2-methylquinoline-4-yl) hydrazine derivatives 9a-9n possessing 4-quinolylhydrazone and artemisinin cores were herein synthesized and evaluated for their activities against cysteine protease falcipain- 2 of Plasmodium falciparum. The structures were clearly confirmed by elemental analysis, 1H NMR, and mass spectra. The pharmacological results indicated that all compounds showed excellent activity against recombinant falcipain-2 (IC50 = 0.15-2.28 μM). The best one of this series was compound 9d (IC50 = 0.15 μM). The molecular docking results showed that the compound 9d made close contact with the key active site of cysteine protease falcipain-2.