1-(ChloroMethyl)-4-phenoxybenzene

Base Information

• Chemical Name: 1-(ChloroMethyl)-4-phenoxybenzene
• CAS No.: 4039-92-3
• Molecular Formula: C13H11ClO
• Molecular Weight: 218.683
• Hs Code.: 2909309090
• Mol file: 4039-92-3.mol

Synonyms:4-phenoxybenzyl chloride;Benzene, 1-(chloromethyl)-4-phenoxy-;phenoxybenzyl chloride;p-phenoxy benzyl chloride;4-phenoxyphenylmethyl chloride;1-chloromethyl-4-phenoxy-benzene;

Chemical Property of 1-(ChloroMethyl)-4-phenoxybenzene

Chemical Property:

• PSA: 9.23000
• LogP: 4.21770
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C

Purity/Quality:

98.5% ^*data from raw suppliers

1-(Chloromethyl)-4-phenoxybenzene ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-(ChloroMethyl)-4-phenoxybenzene

There total 8 articles about 1-(ChloroMethyl)-4-phenoxybenzene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

(4-phenoxyphenyl)methanol (2215-78-3) → 4-phenoxybenzyl chloride (4039-92-3)

Guidance literature:

With thionyl chloride; In chloroform; Heating / reflux;

Reference yield: 30.0%

formaldehyd (50-00-0,30525-89-4,61233-19-0) + diphenylether (101-84-8) → 4-phenoxybenzyl chloride (4039-92-3)

Guidance literature:

With hydrogenchloride; In acetone; at 0 ℃; for 7h;

DOI:10.1016/j.bmc.2006.07.011

Reference yield:

4-phenoxy benzaldehyde (67-36-7) → 4-phenoxybenzyl chloride (4039-92-3)

Guidance literature:

Multi-step reaction with 2 steps

1: 84 percent / NaBH₄ / ethanol / 2 h / 20 °C

2: Ph₃P; Cl₄C / acetonitrile / 20 °C

With tetrachloromethane; sodium tetrahydroborate; triphenylphosphine; In ethanol; acetonitrile; 1: Reduction / 2: Chlorination;

DOI:10.1021/jm9905007

upstream raw materials:

formaldehyd

diphenylether

(4-phenoxyphenyl)methanol

4-phenoxy benzaldehyde

Downstream raw materials:

4-Methoxymethyl-diphenylether

C₁₉H₁₅NO₄

1-(4-phenoxy-benzyl)-piperidine-4-carboxylic acid amide

3,3,3-Trifluoro-2-methyl-2-(4-phenoxy-benzyloxy)-propionic acid

Refernces

• 1、 Koguchi, Shinichi,Shibuya, Yuga,Igarashi, Yusuke,Takemura, Haruka. "Ionic-Liquid-Supported 1,3-Dimethylimidazolidin-2-one: Application as a Reusable Halogenation Reagent". supporting information. p. 943 - 946. Retrieved 2019/05/10.
• 2、 Chen, Jia,Lin, Jin-Hong,Xiao, Ji-Chang. "Dehydroxylation of alcohols for nucleophilic substitution". . p. 7034 - 7037. Retrieved 2018/07/05.