4-Phenoxybenzoic acid methyl ester

Base Information

• Chemical Name: 4-Phenoxybenzoic acid methyl ester
• CAS No.: 21218-94-0
• Molecular Formula: C14H12O3
• Molecular Weight: 228.247
• Hs Code.: 2918990090
• Mol file: 21218-94-0.mol

Synonyms:Benzoic acid,p-phenoxy-,methyl ester;p-Phenoxybenzoesaeuremethylester;4-Phenoxy-benzoesaeure-methylester;4-Phenoxy-benzoic acid methyl ester;4'-Carbomethoxy-diphenylaether;Methyl-p-phenoxy-benzoat;

Chemical Property of 4-Phenoxybenzoic acid methyl ester

Chemical Property:

• PSA: 35.53000
• LogP: 3.26550

Purity/Quality:

99% ^*data from raw suppliers

Methyl4-Phenoxybenzoate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Uses: Methyl 4-Phenoxybenzoate is useful for preparing potential InhA reductase inhibitors.

Technology Process of 4-Phenoxybenzoic acid methyl ester

There total 25 articles about 4-Phenoxybenzoic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

[4-(methoxycarbonyl)phenyl](2,4,6-trimethoxyphenyl)iodonium tosylate + phenol (108-95-2,27073-41-2) → methyl 4-phenoxybenzoate (21218-94-0)

Guidance literature:

With potassium carbonate; In toluene; at 55 ℃; for 2h; Sealed tube;

DOI:10.1002/adsc.201901187

Reference yield: 94.0%

4-methoxycarbonylphenyl bromide (619-42-1) + phenol (108-95-2,27073-41-2) → methyl 4-phenoxybenzoate (21218-94-0)

Guidance literature:

With potassium phosphate; copper(l) iodide; N,N’-bis(2-phenylphenyl)oxalic acid; In N,N-dimethyl-formamide; at 90 ℃; for 24h; Schlenk technique; Inert atmosphere; Sealed tube;

DOI:10.1021/acs.joc.7b00493

Reference yield: 91.0%

Methyl 4-chlorobenzoate (1126-46-1) + phenol (108-95-2,27073-41-2) → methyl 4-phenoxybenzoate (21218-94-0)

Guidance literature:

With potassium phosphate; 2-((di-adamantan-1-yl)phosphaneyl)-1-(2,6-diisopropylphenyl)-1H-imidazole; palladium diacetate; In toluene; at 100 ℃; for 10h; Inert atmosphere;

DOI:10.1039/b915249k

upstream raw materials:

4-methoxycarbonylphenyl bromide

potassium phenolate

4-Phenoxybenzoic acid

methanol

Downstream raw materials:

4-(4-chloromethyl-phenoxy)-benzoic acid methyl ester

methyl 4-(4-bromophenoxy)benzoate

2-Naphthalenemethanol

(4-phenoxyphenyl)methanol