Methyl-5-benzyloxycarbonyl-4-(2-methoxycarbonylethyl)-2-hydroxyiminomethylpyrrol-3-propionat

Base Information

• Chemical Name: Methyl-5-benzyloxycarbonyl-4-(2-methoxycarbonylethyl)-2-hydroxyiminomethylpyrrol-3-propionat
• CAS No.: 73870-08-3
• Molecular Formula: C₂₁H₂₄N₂O₇
• Molecular Weight: 416.431
• Mol file: 73870-08-3.mol

Synonyms:Methyl-5-benzyloxycarbonyl-4-(2-methoxycarbonylethyl)-2-hydroxyiminomethylpyrrol-3-propionat

Chemical Property of Methyl-5-benzyloxycarbonyl-4-(2-methoxycarbonylethyl)-2-hydroxyiminomethylpyrrol-3-propionat

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Methyl-5-benzyloxycarbonyl-4-(2-methoxycarbonylethyl)-2-hydroxyiminomethylpyrrol-3-propionat

There total 7 articles about Methyl-5-benzyloxycarbonyl-4-(2-methoxycarbonylethyl)-2-hydroxyiminomethylpyrrol-3-propionat which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

Methyl-5-benzyloxycarbonyl-2-formyl-4-(2-methoxycarbonylethyl)pyrrol-3-propionat (73870-07-2) → Methyl-5-benzyloxycarbonyl-4-(2-methoxycarbonylethyl)-2-hydroxyiminomethylpyrrol-3-propionat (73870-08-3)

Guidance literature:

With hydroxylamine hydrochloride; sodium ethanolate; In water; for 1h; Heating;

Reference yield:

3-(2-ethoxycarbonylethyl)-4-formyl-5-methylpyrrole-2-carboxylate (58950-57-5) → Methyl-5-benzyloxycarbonyl-4-(2-methoxycarbonylethyl)-2-hydroxyiminomethylpyrrol-3-propionat (73870-08-3)

Guidance literature:

Multi-step reaction with 7 steps

1: 83 percent / pyridine; various solvent(s) / 5 h / 90 - 100 °C

2: 71 percent / 1) H₂ / 1) Raney - Ni / 1) MeOH, 2) 60 deg C, 30 min

3: 93 percent / HCl / 24 h / 25 °C

4: 82 percent / Na / 1) steam bath, 1 h, 2) 10 Torr, 3 h

5: 92 percent / HCl / 24 h / 25 °C

6: 1) SO₂Cl₂, 3) NaOAc/H₂O / 1) CH₂Cl₂, 0 deg C, 15 min, 2) 20 deg C, 75 min, 3) steam bath, 10 min, water

7: 86 percent / NH₂OH*HCl, NaOEt / H₂O / 1 h / Heating

With hydrogenchloride; sulfuryl dichloride; hydroxylamine hydrochloride; water; hydrogen; sodium ethanolate; sodium acetate; sodium; nickel; In pyridine; water;

Reference yield:

Ethyl-3-(2-carboxyvinyl)-5-ethoxycarbonyl-2-methylpyrrol-4-propionat (73870-02-7) → Methyl-5-benzyloxycarbonyl-4-(2-methoxycarbonylethyl)-2-hydroxyiminomethylpyrrol-3-propionat (73870-08-3)

Guidance literature:

Multi-step reaction with 6 steps

1: 71 percent / 1) H₂ / 1) Raney - Ni / 1) MeOH, 2) 60 deg C, 30 min

2: 93 percent / HCl / 24 h / 25 °C

3: 82 percent / Na / 1) steam bath, 1 h, 2) 10 Torr, 3 h

4: 92 percent / HCl / 24 h / 25 °C

5: 1) SO₂Cl₂, 3) NaOAc/H₂O / 1) CH₂Cl₂, 0 deg C, 15 min, 2) 20 deg C, 75 min, 3) steam bath, 10 min, water

6: 86 percent / NH₂OH*HCl, NaOEt / H₂O / 1 h / Heating

With hydrogenchloride; sulfuryl dichloride; hydroxylamine hydrochloride; water; hydrogen; sodium ethanolate; sodium acetate; sodium; nickel; In water;

upstream raw materials:

Methyl-5-benzyloxycarbonyl-2-formyl-4-(2-methoxycarbonylethyl)pyrrol-3-propionat

3-(2-ethoxycarbonylethyl)-4-formyl-5-methylpyrrole-2-carboxylate

4-(2-carboxyethyl)-5-ethoxycarbonyl-2-methylpyrrol-3-propionsaeure

Methyl-5-ethoxycarbonyl-4-(2-methoxycarbonylethyl)-2-methylpyrrol-3-propionat

Downstream raw materials:

Methyl-2-acetamidomethyl-5-benzyloxycarbonyl-4-(2-methoxycarbonylethyl)pyrrol-3-propionat

Methyl-2-aminomethyl-5-benzyloxycarbonyl-4-(2-methoxycarbonylethyl)pyrrol-3-propionat hydrochlorid