5-chloro-2-<2-<(2-hydroxyethyl)amino>ethyl>-10-(phenylmethoxy)anthra<1,9-cd>pyrazol-6(2H)-one

Base Information

• Chemical Name: 5-chloro-2-<2-<(2-hydroxyethyl)amino>ethyl>-10-(phenylmethoxy)anthra<1,9-cd>pyrazol-6(2H)-one
• CAS No.: 88303-58-6
• Molecular Formula: C₂₅H₂₂ClN₃O₃
• Molecular Weight: 447.921
• Mol file: 88303-58-6.mol

Synonyms:5-chloro-2-<2-<(2-hydroxyethyl)amino>ethyl>-10-(phenylmethoxy)anthra<1,9-cd>pyrazol-6(2H)-one

Chemical Property of 5-chloro-2-<2-<(2-hydroxyethyl)amino>ethyl>-10-(phenylmethoxy)anthra<1,9-cd>pyrazol-6(2H)-one

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 5-chloro-2-<2-<(2-hydroxyethyl)amino>ethyl>-10-(phenylmethoxy)anthra<1,9-cd>pyrazol-6(2H)-one

There total 4 articles about 5-chloro-2-<2-<(2-hydroxyethyl)amino>ethyl>-10-(phenylmethoxy)anthra<1,9-cd>pyrazol-6(2H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

benzyl bromide (100-39-0) → 5-chloro-2-<2-<(2-hydroxyethyl)amino>ethyl>-10-(phenylmethoxy)anthra<1,9-cd>pyrazol-6(2H)-one (88303-58-6)

Guidance literature:

Multi-step reaction with 2 steps

1: 93 percent / K₂CO₃ / acetone / Heating

2: dimethylsulfoxide

With potassium carbonate; In dimethyl sulfoxide; acetone;

DOI:10.1021/jm00369a002

Reference yield:

1,4-dichloro-5-(phenylmethoxy)-9,10-anthracenedione (88303-56-4) + <2-<(2-hydroxyethyl)amino>ethyl>hydrazine (88303-65-5) → 5-chloro-2-<2-<(2-hydroxyethyl)amino>ethyl>-7-(phenylmethoxy)anthra<1,9-cd>pyrazol-6(2H)-one (88303-57-5) + 5-chloro-2-<2-<(2-hydroxyethyl)amino>ethyl>-10-(phenylmethoxy)anthra<1,9-cd>pyrazol-6(2H)-one (88303-58-6)

Guidance literature:

With pyridine; at 80 ℃; for 16h;

DOI:10.1002/jhet.5570260117

Reference yield:

benzyl bromide (100-39-0) → 5-chloro-2-<2-<(2-hydroxyethyl)amino>ethyl>-10-(phenylmethoxy)anthra<1,9-cd>pyrazol-6(2H)-one (88303-58-6)

Guidance literature:

Multi-step reaction with 2 steps

1: 87 percent / K₂CO₃ / acetone / 72 h / Heating

2: 2.5 g / pyridine / 16 h / 80 °C

With pyridine; potassium carbonate; In acetone;

DOI:10.1002/jhet.5570260117

upstream raw materials:

1,4-dichloro-5-(phenylmethoxy)-9,10-anthracenedione

<2-<(2-hydroxyethyl)amino>ethyl>hydrazine

benzyl bromide

Downstream raw materials:

2-<2-<(2-hydroxyethyl)amino>ethyl>-5-<<2-<(2-hydroxyethyl)amino>ethyl>amino>-10-(phenylmethoxy)anthra<1,9-cd>pyrazol-6(2H)-one