5-(benzoxazol-2-yl)-2-(2-phenylethyl)-1-(tetrahydropyran-4-yl)benzimidazole

Base Information

Chemical Name:5-(benzoxazol-2-yl)-2-(2-phenylethyl)-1-(tetrahydropyran-4-yl)benzimidazole
CAS No.:1256967-31-3
Molecular Formula:C₂₇H₂₅N₃O₂
Molecular Weight:423.514
Hs Code.:

Synonyms:5-(benzoxazol-2-yl)-2-(2-phenylethyl)-1-(tetrahydropyran-4-yl)benzimidazole

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Chemical Property of 5-(benzoxazol-2-yl)-2-(2-phenylethyl)-1-(tetrahydropyran-4-yl)benzimidazole

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Technology Process of 5-(benzoxazol-2-yl)-2-(2-phenylethyl)-1-(tetrahydropyran-4-yl)benzimidazole

There total 9 articles about 5-(benzoxazol-2-yl)-2-(2-phenylethyl)-1-(tetrahydropyran-4-yl)benzimidazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

: 1256967-25-5
5-(benzoxazol-2-yl)-2-trans-cinnamyl-1-(tehrahydropyran-4-yl)benzimidazole

: 1256967-31-3
5-(benzoxazol-2-yl)-2-(2-phenylethyl)-1-(tetrahydropyran-4-yl)benzimidazole

Guidance literature:: With hydrogen; palladium 10% on activated carbon; In tetrahydrofuran; at 20 ℃; for 17h;

Reference yield:

: 453-71-4
3-nitro-4-fluorobenzoic acid

: 1256967-31-3
5-(benzoxazol-2-yl)-2-(2-phenylethyl)-1-(tetrahydropyran-4-yl)benzimidazole

Guidance literature:: Multi-step reaction with 5 steps

1.1: triethylamine / ethanol / 14 h / Reflux

2.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / chloroform / 3 h / 20 °C

2.2: 10 h / Reflux

3.1: hydrogen / 5%-palladium/activated carbon / tetrahydrofuran; methanol / 20 °C

4.1: Oxone / N,N-dimethyl-formamide / 3 h / 20 °C

5.1: hydrogen / palladium 10% on activated carbon / tetrahydrofuran / 17 h / 20 °C

With Oxone; hydrogen; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; 5%-palladium/activated carbon; palladium 10% on activated carbon; In tetrahydrofuran; methanol; ethanol; chloroform; N,N-dimethyl-formamide;

Reference yield:

: 95-55-6
2-amino-phenol

: 1256967-31-3
5-(benzoxazol-2-yl)-2-(2-phenylethyl)-1-(tetrahydropyran-4-yl)benzimidazole

Guidance literature:: Multi-step reaction with 4 steps

1.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / chloroform / 3 h / 20 °C

1.2: 10 h / Reflux

2.1: hydrogen / 5%-palladium/activated carbon / tetrahydrofuran; methanol / 20 °C

3.1: Oxone / N,N-dimethyl-formamide / 3 h / 20 °C

4.1: hydrogen / palladium 10% on activated carbon / tetrahydrofuran / 17 h / 20 °C

With Oxone; hydrogen; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; 5%-palladium/activated carbon; palladium 10% on activated carbon; In tetrahydrofuran; methanol; chloroform; N,N-dimethyl-formamide;