3-(2-chloroethyl)-9-oxo-2-methyl-6,7,8,9-tetrahydro-4H-pyrido-[1,2-a]pyrimidin-4-one

Base Information

• Chemical Name: 3-(2-chloroethyl)-9-oxo-2-methyl-6,7,8,9-tetrahydro-4H-pyrido-[1,2-a]pyrimidin-4-one
• CAS No.: 1138463-56-5
• Molecular Formula: C₁₁H₁₃ClN₂O₂
• Molecular Weight: 240.689
• Mol file: 1138463-56-5.mol

Synonyms:3-(2-chloroethyl)-9-oxo-2-methyl-6,7,8,9-tetrahydro-4H-pyrido-[1,2-a]pyrimidin-4-one

Chemical Property of 3-(2-chloroethyl)-9-oxo-2-methyl-6,7,8,9-tetrahydro-4H-pyrido-[1,2-a]pyrimidin-4-one

Chemical Property:

Purity/Quality:

> 95% ^*data from raw suppliers

3-(2-Chloroethyl)-7,8-dihydro-2-methyl-4H-pyrido[1,2-a]pyrimidine-4,9(6H)-dione ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-(2-chloroethyl)-9-oxo-2-methyl-6,7,8,9-tetrahydro-4H-pyrido-[1,2-a]pyrimidin-4-one

There total 7 articles about 3-(2-chloroethyl)-9-oxo-2-methyl-6,7,8,9-tetrahydro-4H-pyrido-[1,2-a]pyrimidin-4-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3-(2-chloroethyl)-9-hydroxy-2-methyl-6,7,8,9-tetrahydro-4H-pyrido[1,2-a]pyrimidin-4-one (130049-82-0) → 3-(2-chloroethyl)-9-oxo-2-methyl-6,7,8,9-tetrahydro-4H-pyrido-[1,2-a]pyrimidin-4-one (1138463-56-5)

Guidance literature:

3-(2-chloroethyl)-9-hydroxy-2-methyl-6,7,8,9-tetrahydro-4H-pyrido[1,2-a]pyrimidin-4-one; With oxalyl dichloride; dimethyl sulfoxide; In dichloromethane; at -65 ℃;

With triethylamine; In dichloromethane;

Reference yield:

3-(2-chloroethyl)-9-hydroxy-2-methyl-6,7,8,9-tetrahydro-4H-pyrido[1,2-a]pyrimidin-4-one (130049-82-0) + Chloro-oxo-acetic acid (4732-69-8) → 3-(2-chloroethyl)-9-oxo-2-methyl-6,7,8,9-tetrahydro-4H-pyrido-[1,2-a]pyrimidin-4-one (1138463-56-5)

Guidance literature:

With dimethyl sulfoxide; triethylamine; In dichloromethane;

Reference yield:

3-(2-chloroethyl)-9-hydroxy-2-methyl-4H-pyrido[1,2-a]pyrimidin-4-one monohydrochloride (849727-62-4) → 3-(2-chloroethyl)-9-oxo-2-methyl-6,7,8,9-tetrahydro-4H-pyrido-[1,2-a]pyrimidin-4-one (1138463-56-5)

Guidance literature:

Multi-step reaction with 2 steps

1: acetic acid / palladium-carbon

2: triethylamine; dimethyl sulfoxide / dichloromethane

With acetic acid; dimethyl sulfoxide; triethylamine; palladium-carbon; In dichloromethane;

upstream raw materials:

3-(2-chloroethyl)-9-hydroxy-2-methyl-6,7,8,9-tetrahydro-4H-pyrido[1,2-a]pyrimidin-4-one

3-acetyl-2-oxo-4,5-dihydrofuran

Chloro-oxo-acetic acid

2-amino-3-benzyloxypyridine

Downstream raw materials:

(+)-Paliperidone

paliperidone