Methyl (3S)-3-ethoxy-3-(4-{[trans-4-(trifluoromethyl)cyclohexyl]methoxy}phenyl)propionate

Base Information

Chemical Name:Methyl (3S)-3-ethoxy-3-(4-{[trans-4-(trifluoromethyl)cyclohexyl]methoxy}phenyl)propionate
CAS No.:1202577-62-5
Molecular Formula:C₂₀H₂₇F₃O₄
Molecular Weight:388.427
Hs Code.:

Synonyms:Methyl (3S)-3-ethoxy-3-(4-{[trans-4-(trifluoromethyl)cyclohexyl]methoxy}phenyl)propionate

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Chemical Property of Methyl (3S)-3-ethoxy-3-(4-{[trans-4-(trifluoromethyl)cyclohexyl]methoxy}phenyl)propionate

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Technology Process of Methyl (3S)-3-ethoxy-3-(4-{[trans-4-(trifluoromethyl)cyclohexyl]methoxy}phenyl)propionate

There total 4 articles about Methyl (3S)-3-ethoxy-3-(4-{[trans-4-(trifluoromethyl)cyclohexyl]methoxy}phenyl)propionate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 501334-19-6
methyl 3-[4-(tert-butyldimethylsilyloxybenzyl)phenyl]-3-oxopropanoate

: 1202577-62-5
Methyl (3S)-3-ethoxy-3-(4-{[trans-4-(trifluoromethyl)cyclohexyl]methoxy}phenyl)propionate

Guidance literature:: Multi-step reaction with 4 steps

1: triethylamine; formic acid / Noyori's catalyst / 0 - 35 °C / Inert atmosphere

2: silver(l) oxide / toluene / 20 - 110 °C / Inert atmosphere

3: tetrabutyl ammonium fluoride / tetrahydrofuran / 1.5 h / 0 °C

4: triphenylphosphine; diethylazodicarboxylate / toluene; tetrahydrofuran / 20 - 50 °C / Inert atmosphere

With formic acid; tetrabutyl ammonium fluoride; triethylamine; triphenylphosphine; silver(l) oxide; diethylazodicarboxylate; Noyori's catalyst; In tetrahydrofuran; toluene;

Reference yield:

: 133261-33-3
trans-4-trifluoro-methyl-cyclohexanecarboxylic acid

: 1202577-62-5
Methyl (3S)-3-ethoxy-3-(4-{[trans-4-(trifluoromethyl)cyclohexyl]methoxy}phenyl)propionate

Guidance literature:: Multi-step reaction with 2 steps

1: lithium aluminium tetrahydride / tetrahydrofuran / 0 - 20 °C

2: triphenylphosphine; diethylazodicarboxylate / toluene; tetrahydrofuran / 20 - 50 °C / Inert atmosphere

With lithium aluminium tetrahydride; triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; toluene;

Reference yield:

: 1202577-54-5
Methyl (3S)-3-[4-(tert-butyldimethylsilyloxy)phenyl]-3-hydroxypropionate

: 1202577-62-5
Methyl (3S)-3-ethoxy-3-(4-{[trans-4-(trifluoromethyl)cyclohexyl]methoxy}phenyl)propionate

Guidance literature:: Multi-step reaction with 3 steps

1: silver(l) oxide / toluene / 20 - 110 °C / Inert atmosphere

2: tetrabutyl ammonium fluoride / tetrahydrofuran / 1.5 h / 0 °C

3: triphenylphosphine; diethylazodicarboxylate / toluene; tetrahydrofuran / 20 - 50 °C / Inert atmosphere

With tetrabutyl ammonium fluoride; triphenylphosphine; silver(l) oxide; diethylazodicarboxylate; In tetrahydrofuran; toluene;