4-(4-METHOXY-PHENYL)-3-OXO-BUTYRIC ACID METHYL ESTER

Base Information

• Chemical Name: 4-(4-METHOXY-PHENYL)-3-OXO-BUTYRIC ACID METHYL ESTER
• CAS No.: 100117-84-8
• Molecular Formula: C₁₂H₁₄O₄
• Molecular Weight: 222.241
• Mol file: 100117-84-8.mol

Synonyms:methyl 4-(4-methoxyphenyl)-3-oxobutanoate

Chemical Property of 4-(4-METHOXY-PHENYL)-3-OXO-BUTYRIC ACID METHYL ESTER

Chemical Property:

Purity/Quality:

97% ^*data from raw suppliers

Methyl4-(4-methoxyphenyl)-3-oxobutanoate 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-(4-METHOXY-PHENYL)-3-OXO-BUTYRIC ACID METHYL ESTER

There total 6 articles about 4-(4-METHOXY-PHENYL)-3-OXO-BUTYRIC ACID METHYL ESTER which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

1-bromo-4-methoxy-benzene (104-92-7) + 1,3-bis(trimethylsiloxy)-1-methoxybuta-1,3-diene (74590-73-1,81114-98-9,67609-52-3) → methyl 4-(4-methoxyphenyl)-3-oxobutanoate (100117-84-8)

Guidance literature:

With tri-tert-butyl phosphine; tributyltin fluoride; bis(dibenzylideneacetone)-palladium⁽⁰⁾; In tetrahydrofuran; at 65 ℃; regioselective reaction; Inert atmosphere;

DOI:10.1021/acs.orglett.5b02952

Reference yield: 80.0%

4-Methoxyphenylacetic acid (104-01-8) + monomethyl monopotassium malonate (38330-80-2) → methyl 4-(4-methoxyphenyl)-3-oxobutanoate (100117-84-8)

Guidance literature:

4-Methoxyphenylacetic acid; With Carbonyldiimidazole; In tetrahydrofuran; at 40 ℃; for 1h; Inert atmosphere;

monomethyl monopotassium malonate; With magnesium chloride; at 45 ℃; Inert atmosphere;

DOI:10.1021/acs.orglett.0c00103

Reference yield: 56.0%

acetic acid methyl ester (79-20-9) + 4-methoxyphenyl-acetic chloride (4693-91-8) → methyl 4-(4-methoxyphenyl)-3-oxobutanoate (100117-84-8)

Guidance literature:

acetic acid methyl ester; With lithium diisopropyl amide; In tetrahydrofuran; Inert atmosphere; Cooling;

4-methoxyphenyl-acetic chloride; In tetrahydrofuran; at -78 - 20 ℃; Inert atmosphere;

DOI:10.1055/s-0028-1083298

upstream raw materials:

acetoacetic acid methyl ester

4-methoxyphenyl-acetic chloride

acetic acid methyl ester

C₁₂H₁₄O₃

Downstream raw materials:

3-Amino-4-<4-methoxy-phenyl>-crotonsaeure-methylester

3-(2-Methoxycarbonyl-aethylamino)-4-(4-methoxy-phenyl)-crotonsaeure-methylester

C₁₅H₂₂O₄Si

methyl 2-diazo-4-(4-methoxyphenyl)-3-oxobutanoate