(4R,5S)-3-((1S,3S)-3-((3R,4S)-4-hydroxy-7-(5-(3-phenyl-4-(trifluoromethyl)isoxazol-5-yl)-1,2,4-oxadiazol-3-yl)chroman-3-ylamino)cyclohexanecarbonyl)-4-methyl-5-phenyloxazolidin-2-one

Base Information

Chemical Name:(4R,5S)-3-((1S,3S)-3-((3R,4S)-4-hydroxy-7-(5-(3-phenyl-4-(trifluoromethyl)isoxazol-5-yl)-1,2,4-oxadiazol-3-yl)chroman-3-ylamino)cyclohexanecarbonyl)-4-methyl-5-phenyloxazolidin-2-one
CAS No.:1374445-42-7
Molecular Formula:C₃₈H₃₄F₃N₅O₇
Molecular Weight:729.712
Hs Code.:

(4R,5S)-3-((1S,3S)-3-((3R,4S)-4-hydroxy-7-(5-(3-phenyl-4-(trifluoromethyl)isoxazol-5-yl)-1,2,4-oxadiazol-3-yl)chroman-3-ylamino)cyclohexanecarbonyl)-4-methyl-5-phenyloxazolidin-2-one

Synonyms:(4R,5S)-3-((1S,3S)-3-((3R,4S)-4-hydroxy-7-(5-(3-phenyl-4-(trifluoromethyl)isoxazol-5-yl)-1,2,4-oxadiazol-3-yl)chroman-3-ylamino)cyclohexanecarbonyl)-4-methyl-5-phenyloxazolidin-2-one

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Chemical Property of (4R,5S)-3-((1S,3S)-3-((3R,4S)-4-hydroxy-7-(5-(3-phenyl-4-(trifluoromethyl)isoxazol-5-yl)-1,2,4-oxadiazol-3-yl)chroman-3-ylamino)cyclohexanecarbonyl)-4-methyl-5-phenyloxazolidin-2-one

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Technology Process of (4R,5S)-3-((1S,3S)-3-((3R,4S)-4-hydroxy-7-(5-(3-phenyl-4-(trifluoromethyl)isoxazol-5-yl)-1,2,4-oxadiazol-3-yl)chroman-3-ylamino)cyclohexanecarbonyl)-4-methyl-5-phenyloxazolidin-2-one

There total 15 articles about (4R,5S)-3-((1S,3S)-3-((3R,4S)-4-hydroxy-7-(5-(3-phenyl-4-(trifluoromethyl)isoxazol-5-yl)-1,2,4-oxadiazol-3-yl)chroman-3-ylamino)cyclohexanecarbonyl)-4-methyl-5-phenyloxazolidin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 932-90-1,622-31-1,140461-24-1,140461-25-2,622-32-2
syn-benzaldehyde oxime

: 1374445-42-7
(4R,5S)-3-((1S,3S)-3-((3R,4S)-4-hydroxy-7-(5-(3-phenyl-4-(trifluoromethyl)isoxazol-5-yl)-1,2,4-oxadiazol-3-yl)chroman-3-ylamino)cyclohexanecarbonyl)-4-methyl-5-phenyloxazolidin-2-one

Guidance literature:: Multi-step reaction with 10 steps

1: N-chloro-succinimide / N,N-dimethyl-formamide / 20 °C

2: triethylamine / 1,2-dichloro-ethane / 2.5 h / 70 °C

3: Jones reagent / acetone / 20 °C

4: pyridine; trifluoro-[1,3,5]triazine / dichloromethane / 20 °C

5: N-ethyl-N,N-diisopropylamine / acetonitrile

6: methanol; tin(II) chloride dihdyrate / dichloromethane / 10 h

7: triethylamine / water; tetrahydrofuran / 2 h

8: Lux-Cellulose-2 / ethanol / 35 °C / Resolution of racemate

9: dichloromethane / 2 h

10: triethylamine; sodium tris(acetoxy)borohydride / chloroform

With pyridine; methanol; N-chloro-succinimide; Jones reagent; trifluoro-[1,3,5]triazine; tin(II) chloride dihdyrate; sodium tris(acetoxy)borohydride; triethylamine; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; ethanol; dichloromethane; chloroform; water; 1,2-dichloro-ethane; N,N-dimethyl-formamide; acetone; acetonitrile;

Reference yield:

: 1374445-29-0
(4R,5S)-4-methyl-3-((S)-3-oxocyclohexanecarbonyl)-5-phenyloxazolidin-2-one

: 1374443-95-4
(3R,4S)-3-amino-7-(5-(3-phenyl-4-(trifluoromethyl)isoxazol-5-yl)-1,2,4-oxadiazol-3-yl)chroman-4-ol trifluoroacetate

: 1374445-39-2
(4R,5S)-3-((1S,3R)-3-((3R,4S)-4-hydroxy-7-(5-(3-phenyl-4-(trifluoromethyl)isoxazol-5-yl)-1,2,4-oxadiazol-3-yl)chroman-3-ylamino)cyclohexanecarbonyl)-4-methyl-5-phenyloxazolidin-2-one

: 1374445-42-7
(4R,5S)-3-((1S,3S)-3-((3R,4S)-4-hydroxy-7-(5-(3-phenyl-4-(trifluoromethyl)isoxazol-5-yl)-1,2,4-oxadiazol-3-yl)chroman-3-ylamino)cyclohexanecarbonyl)-4-methyl-5-phenyloxazolidin-2-one

Guidance literature:: With sodium tris(acetoxy)borohydride; triethylamine; In chloroform;

Reference yield:

: 1236188-80-9
3-phenyl-4-(trifluoromethyl)isoxazole-5-carboxylic acid

: 1374445-42-7
(4R,5S)-3-((1S,3S)-3-((3R,4S)-4-hydroxy-7-(5-(3-phenyl-4-(trifluoromethyl)isoxazol-5-yl)-1,2,4-oxadiazol-3-yl)chroman-3-ylamino)cyclohexanecarbonyl)-4-methyl-5-phenyloxazolidin-2-one

Guidance literature:: Multi-step reaction with 7 steps

1: pyridine; trifluoro-[1,3,5]triazine / dichloromethane / 20 °C

2: N-ethyl-N,N-diisopropylamine / acetonitrile

3: methanol; tin(II) chloride dihdyrate / dichloromethane / 10 h

4: triethylamine / water; tetrahydrofuran / 2 h

5: Lux-Cellulose-2 / ethanol / 35 °C / Resolution of racemate

6: dichloromethane / 2 h

7: triethylamine; sodium tris(acetoxy)borohydride / chloroform

With pyridine; methanol; trifluoro-[1,3,5]triazine; tin(II) chloride dihdyrate; sodium tris(acetoxy)borohydride; triethylamine; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; ethanol; dichloromethane; chloroform; water; acetonitrile;