(1S,3S)-3-((3R,4S)-4-hydroxy-7-(5-(3-phenyl-4-(trifluoromethyl)isoxazol-5-yl)-1,2,4-oxadiazol-3-yl)chroman-3-ylamino)cyclohexanecarboxylic acid trifluoroacetate

Base Information

Chemical Name:(1S,3S)-3-((3R,4S)-4-hydroxy-7-(5-(3-phenyl-4-(trifluoromethyl)isoxazol-5-yl)-1,2,4-oxadiazol-3-yl)chroman-3-ylamino)cyclohexanecarboxylic acid trifluoroacetate
CAS No.:1374444-83-3
Molecular Formula:C₂HF₃O₂*C₂₈H₂₅F₃N₄O₆
Molecular Weight:684.549
Hs Code.:

(1S,3S)-3-((3R,4S)-4-hydroxy-7-(5-(3-phenyl-4-(trifluoromethyl)isoxazol-5-yl)-1,2,4-oxadiazol-3-yl)chroman-3-ylamino)cyclohexanecarboxylic acid trifluoroacetate

Synonyms:(1S,3S)-3-((3R,4S)-4-hydroxy-7-(5-(3-phenyl-4-(trifluoromethyl)isoxazol-5-yl)-1,2,4-oxadiazol-3-yl)chroman-3-ylamino)cyclohexanecarboxylic acid trifluoroacetate

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Chemical Property of (1S,3S)-3-((3R,4S)-4-hydroxy-7-(5-(3-phenyl-4-(trifluoromethyl)isoxazol-5-yl)-1,2,4-oxadiazol-3-yl)chroman-3-ylamino)cyclohexanecarboxylic acid trifluoroacetate

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Technology Process of (1S,3S)-3-((3R,4S)-4-hydroxy-7-(5-(3-phenyl-4-(trifluoromethyl)isoxazol-5-yl)-1,2,4-oxadiazol-3-yl)chroman-3-ylamino)cyclohexanecarboxylic acid trifluoroacetate

There total 16 articles about (1S,3S)-3-((3R,4S)-4-hydroxy-7-(5-(3-phenyl-4-(trifluoromethyl)isoxazol-5-yl)-1,2,4-oxadiazol-3-yl)chroman-3-ylamino)cyclohexanecarboxylic acid trifluoroacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 932-90-1,622-31-1,140461-24-1,140461-25-2,622-32-2
syn-benzaldehyde oxime

: 1374444-83-3
(1S,3S)-3-((3R,4S)-4-hydroxy-7-(5-(3-phenyl-4-(trifluoromethyl)isoxazol-5-yl)-1,2,4-oxadiazol-3-yl)chroman-3-ylamino)cyclohexanecarboxylic acid trifluoroacetate

Guidance literature:: Multi-step reaction with 11 steps

1.1: N-chloro-succinimide / N,N-dimethyl-formamide / 20 °C

2.1: triethylamine / 1,2-dichloro-ethane / 2.5 h / 70 °C

3.1: Jones reagent / acetone / 20 °C

4.1: pyridine; trifluoro-[1,3,5]triazine / dichloromethane / 20 °C

5.1: N-ethyl-N,N-diisopropylamine / acetonitrile

6.1: methanol; tin(II) chloride dihdyrate / dichloromethane / 10 h

7.1: triethylamine / water; tetrahydrofuran / 2 h

8.1: Lux-Cellulose-2 / ethanol / 35 °C / Resolution of racemate

9.1: dichloromethane / 2 h

10.1: triethylamine; sodium tris(acetoxy)borohydride / chloroform

11.1: lithium hydroxide; dihydrogen peroxide / tetrahydrofuran / 1 h / 0 °C

11.2: 1.5 h / 20 °C / pH 9

With pyridine; methanol; N-chloro-succinimide; Jones reagent; trifluoro-[1,3,5]triazine; tin(II) chloride dihdyrate; dihydrogen peroxide; sodium tris(acetoxy)borohydride; triethylamine; N-ethyl-N,N-diisopropylamine; lithium hydroxide; In tetrahydrofuran; ethanol; dichloromethane; chloroform; water; 1,2-dichloro-ethane; N,N-dimethyl-formamide; acetone; acetonitrile;

Reference yield:

: 1374445-42-7
(4R,5S)-3-((1S,3S)-3-((3R,4S)-4-hydroxy-7-(5-(3-phenyl-4-(trifluoromethyl)isoxazol-5-yl)-1,2,4-oxadiazol-3-yl)chroman-3-ylamino)cyclohexanecarbonyl)-4-methyl-5-phenyloxazolidin-2-one

: 76-05-1
trifluoroacetic acid

: 1374444-83-3
(1S,3S)-3-((3R,4S)-4-hydroxy-7-(5-(3-phenyl-4-(trifluoromethyl)isoxazol-5-yl)-1,2,4-oxadiazol-3-yl)chroman-3-ylamino)cyclohexanecarboxylic acid trifluoroacetate

Guidance literature:: (4R,5S)-3-((1S,3S)-3-((3R,4S)-4-hydroxy-7-(5-(3-phenyl-4-(trifluoromethyl)isoxazol-5-yl)-1,2,4-oxadiazol-3-yl)chroman-3-ylamino)cyclohexanecarbonyl)-4-methyl-5-phenyloxazolidin-2-one; With dihydrogen peroxide; lithium hydroxide; In tetrahydrofuran; at 0 ℃; for 1h;

With hydrogenchloride; sodium hydrogencarbonate; In water; at 20 ℃; for 1.5h; pH=9;

trifluoroacetic acid;

Reference yield:

: 1236188-80-9
3-phenyl-4-(trifluoromethyl)isoxazole-5-carboxylic acid

: 1374444-83-3
(1S,3S)-3-((3R,4S)-4-hydroxy-7-(5-(3-phenyl-4-(trifluoromethyl)isoxazol-5-yl)-1,2,4-oxadiazol-3-yl)chroman-3-ylamino)cyclohexanecarboxylic acid trifluoroacetate

Guidance literature:: Multi-step reaction with 8 steps

1.1: pyridine; trifluoro-[1,3,5]triazine / dichloromethane / 20 °C

2.1: N-ethyl-N,N-diisopropylamine / acetonitrile

3.1: methanol; tin(II) chloride dihdyrate / dichloromethane / 10 h

4.1: triethylamine / water; tetrahydrofuran / 2 h

5.1: Lux-Cellulose-2 / ethanol / 35 °C / Resolution of racemate

6.1: dichloromethane / 2 h

7.1: triethylamine; sodium tris(acetoxy)borohydride / chloroform

8.1: lithium hydroxide; dihydrogen peroxide / tetrahydrofuran / 1 h / 0 °C

8.2: 1.5 h / 20 °C / pH 9

With pyridine; methanol; trifluoro-[1,3,5]triazine; tin(II) chloride dihdyrate; dihydrogen peroxide; sodium tris(acetoxy)borohydride; triethylamine; N-ethyl-N,N-diisopropylamine; lithium hydroxide; In tetrahydrofuran; ethanol; dichloromethane; chloroform; water; acetonitrile;