3-{[1-({[(2S)-4-{[tert-butyl(dimethyl)silyl]oxy}-2-(3,4-dichlorophenyl)butyl]amino}carbonyl)-3-cyano-2-naphthyl]oxy}propyl methanesulfonate

Base Information

Chemical Name:3-{[1-({[(2S)-4-{[tert-butyl(dimethyl)silyl]oxy}-2-(3,4-dichlorophenyl)butyl]amino}carbonyl)-3-cyano-2-naphthyl]oxy}propyl methanesulfonate
CAS No.:367259-84-5
Molecular Formula:C₃₂H₄₀Cl₂N₂O₆SSi
Molecular Weight:679.737
Hs Code.:

Synonyms:3-{[1-({[(2S)-4-{[tert-butyl(dimethyl)silyl]oxy}-2-(3,4-dichlorophenyl)butyl]amino}carbonyl)-3-cyano-2-naphthyl]oxy}propyl methanesulfonate

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Chemical Property of 3-{[1-({[(2S)-4-{[tert-butyl(dimethyl)silyl]oxy}-2-(3,4-dichlorophenyl)butyl]amino}carbonyl)-3-cyano-2-naphthyl]oxy}propyl methanesulfonate

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Technology Process of 3-{[1-({[(2S)-4-{[tert-butyl(dimethyl)silyl]oxy}-2-(3,4-dichlorophenyl)butyl]amino}carbonyl)-3-cyano-2-naphthyl]oxy}propyl methanesulfonate

There total 5 articles about 3-{[1-({[(2S)-4-{[tert-butyl(dimethyl)silyl]oxy}-2-(3,4-dichlorophenyl)butyl]amino}carbonyl)-3-cyano-2-naphthyl]oxy}propyl methanesulfonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

: 124-63-0
methanesulfonyl chloride

: 367259-83-4
N-[(2S)-4-{[tert-butyl(dimethyl)silyl]oxy}-2-(3,4-dichlorophenyl)butyl]-3-cyano-2-(3-hydroxypropoxy)-1-naphthamide

: 367259-84-5
3-{[1-({[(2S)-4-{[tert-butyl(dimethyl)silyl]oxy}-2-(3,4-dichlorophenyl)butyl]amino}carbonyl)-3-cyano-2-naphthyl]oxy}propyl methanesulfonate

Guidance literature:: With triethylamine; In dichloromethane; at 0 - 20 ℃;
DOI:10.1016/j.bmc.2004.03.015

Reference yield:

: 263388-13-2
2-Methoxy-3-cyano-1-naphthoyl Chloride

: 367259-84-5
3-{[1-({[(2S)-4-{[tert-butyl(dimethyl)silyl]oxy}-2-(3,4-dichlorophenyl)butyl]amino}carbonyl)-3-cyano-2-naphthyl]oxy}propyl methanesulfonate

Guidance literature:: Multi-step reaction with 5 steps

1: 97 percent / aq. NaOH / CH₂Cl₂ / 0 - 20 °C

2: 94 percent / 4-(dimethylamino)pyridine; triethylamine / CH₂Cl₂ / 20 °C

3: 88 percent / magnesium; iodine / benzene; diethyl ether / 1 h / Heating

4: 36 percent / K₂CO₃ / dimethylformamide / 4 h / 100 °C

5: 97 percent / triethylamine / CH₂Cl₂ / 0 - 20 °C

With dmap; sodium hydroxide; iodine; potassium carbonate; magnesium; triethylamine; In diethyl ether; dichloromethane; N,N-dimethyl-formamide; benzene;
DOI:10.1016/j.bmc.2004.03.015

Reference yield:

: 263862-54-0
3-cyano-N-[(2S)-2-(3,4-dichlorophenyl)-4-hydroxybutyl]-2-methoxy-1-naphthamide

: 367259-84-5
3-{[1-({[(2S)-4-{[tert-butyl(dimethyl)silyl]oxy}-2-(3,4-dichlorophenyl)butyl]amino}carbonyl)-3-cyano-2-naphthyl]oxy}propyl methanesulfonate

Guidance literature:: Multi-step reaction with 4 steps

1: 94 percent / 4-(dimethylamino)pyridine; triethylamine / CH₂Cl₂ / 20 °C

2: 88 percent / magnesium; iodine / benzene; diethyl ether / 1 h / Heating

3: 36 percent / K₂CO₃ / dimethylformamide / 4 h / 100 °C

4: 97 percent / triethylamine / CH₂Cl₂ / 0 - 20 °C

With dmap; iodine; potassium carbonate; magnesium; triethylamine; In diethyl ether; dichloromethane; N,N-dimethyl-formamide; benzene;
DOI:10.1016/j.bmc.2004.03.015