methyl 3-(3,5-dimethoxyphenyl)-4-(4-methoxyphenyl)butanoate

Base Information

• Chemical Name: methyl 3-(3,5-dimethoxyphenyl)-4-(4-methoxyphenyl)butanoate
• CAS No.: 1610044-68-2
• Molecular Formula: C₂₀H₂₄O₅
• Molecular Weight: 344.408
• Mol file: 1610044-68-2.mol

Synonyms:methyl 3-(3,5-dimethoxyphenyl)-4-(4-methoxyphenyl)butanoate

Chemical Property of methyl 3-(3,5-dimethoxyphenyl)-4-(4-methoxyphenyl)butanoate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of methyl 3-(3,5-dimethoxyphenyl)-4-(4-methoxyphenyl)butanoate

There total 2 articles about methyl 3-(3,5-dimethoxyphenyl)-4-(4-methoxyphenyl)butanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

methyl 3-(3,5-dimethoxyphenyl)acrylate (76104-60-4) + 4-methoxybenzylmagnesium chloride (38769-92-5) → methyl 3-(3,5-dimethoxyphenyl)-4-(4-methoxyphenyl)butanoate (1610044-68-2)

Guidance literature:

methyl 3-(3,5-dimethoxyphenyl)acrylate; With copper(l) iodide; N,N,N,N,-tetramethylethylenediamine; In tetrahydrofuran; at 20 ℃; for 0.25h; Inert atmosphere; Schlenk technique;

4-methoxybenzylmagnesium chloride; In tetrahydrofuran; at -78 ℃; Inert atmosphere; Schlenk technique;

DOI:10.1002/anie.201310676

Reference yield:

3-(3,5-dimethoxyphenyl)acrylic acid (16909-11-8) → methyl 3-(3,5-dimethoxyphenyl)-4-(4-methoxyphenyl)butanoate (1610044-68-2)

Guidance literature:

Multi-step reaction with 2 steps

1.1: sulfuric acid / 12 h / 70 °C / Inert atmosphere; Schlenk technique

2.1: copper(l) iodide; N,N,N,N,-tetramethylethylenediamine / tetrahydrofuran / 0.25 h / 20 °C / Inert atmosphere; Schlenk technique

2.2: -78 °C / Inert atmosphere; Schlenk technique

With copper(l) iodide; N,N,N,N,-tetramethylethylenediamine; sulfuric acid; In tetrahydrofuran;

DOI:10.1002/anie.201310676

Reference yield:

methyl 3-(3,5-dimethoxyphenyl)-4-(4-methoxyphenyl)butanoate (1610044-68-2) → 3-(3,5-dimethoxyphenyl)-4-(4-methoxyphenyl)butanoic acid (1610044-64-8)

Guidance literature:

With sodium hydroxide; In methanol; at 70 ℃; for 2h; Inert atmosphere; Schlenk technique;

DOI:10.1002/anie.201310676

upstream raw materials:

3-(3,5-dimethoxyphenyl)acrylic acid

methyl 3-(3,5-dimethoxyphenyl)acrylate

4-methoxybenzylmagnesium chloride

Downstream raw materials:

4,6-dimethoxy-1-(4-methoxybenzyl)-1H-indene-1-carboxylic acid

5,7-dimethoxy-3-(4-methoxybenzyl)-1-(4-methoxyphenyl)-1H-indene

1-(3,5-dimethoxyphenyl)-5,7-dimethoxy-3-(4-methoxybenzyl)-1H-indene

3-(3,5-dimethoxyphenyl)-4-(4-methoxyphenyl)butanoic acid