phenyl (E)-β-(trifluoromethyl)vinyl sulfide

Base Information

• Chemical Name: phenyl (E)-β-(trifluoromethyl)vinyl sulfide
• CAS No.: 102687-66-1
• Molecular Formula: C₉H₇F₃S
• Molecular Weight: 204.216
• Mol file: 102687-66-1.mol

Synonyms:phenyl (E)-β-(trifluoromethyl)vinyl sulfide

Chemical Property of phenyl (E)-β-(trifluoromethyl)vinyl sulfide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of phenyl (E)-β-(trifluoromethyl)vinyl sulfide

There total 5 articles about phenyl (E)-β-(trifluoromethyl)vinyl sulfide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 48.0%

2-bromo-3,3,3-trifluoropropene (1514-82-5) + thiophenol (108-98-5) → phenyl (E)-β-(trifluoromethyl)vinyl sulfide (102687-66-1)

Guidance literature:

With potassium hydroxide; In ethanol; at 0 - 20 ℃;

DOI:10.1039/c8ob00293b

Reference yield: 23.0%

2,3,3,3-tetrafluoro-propene (754-12-1) + thiophenol (108-98-5) → phenyl (E)-β-(trifluoromethyl)vinyl sulfide (102687-66-1)

Guidance literature:

thiophenol; With sodium hydride; In hexane; N,N-dimethyl-formamide; mineral oil; at 0 - 20 ℃; for 0.5h; Inert atmosphere;

2,3,3,3-tetrafluoro-propene; In hexane; N,N-dimethyl-formamide; mineral oil; at 20 ℃; for 3h; Inert atmosphere;

DOI:10.1002/ejoc.201901445

Reference yield:

2-bromo-3,3,3-trifluoropropene (1514-82-5) + thiophenol (108-98-5) → phenyl (E)-β-(trifluoromethyl)vinyl sulfide (102687-66-1) + phenyl (Z)-β-(trifluoromethyl)vinyl sulfide

Guidance literature:

With potassium hydroxide; In ethanol; at 0 - 20 ℃;

DOI:10.1016/j.tetlet.2007.03.105

upstream raw materials:

(Z)-1-chloro-3,3,3-trifluoro-1-propene

thiophenol

isobutyraldehyde

2-(trifluoromethyl)-1-(phenylsulfenyl)vinyltrimethylsilane

Downstream raw materials:

2-(trifluoromethyl)-1-(phenylsulfenyl)vinyltrimethylsilane

(E)-diphenyl-β-(trifluoromethyl)vinylsulfonium trifluoromethanesulfonate

(E)-((3,3,3-trifluoroprop-1-en-1-yl)sulfinyl)benzene

trans-2-Trifluoromethyl-3-phenylsulfonyloxirane

Refernces

• 1、 Murray, Ben J.,Ball, Ellis D.,Harsanyi, Antal,Sandford, Graham. "2,3,3,3-Tetrafluoropropene (HFO-1234yf) as a CF3-Building Block: Synthesis of Enol Ethers and Vinyl Sulfides". supporting information. p. 7666 - 7672. Retrieved 2019/12/24.
• 2、 Hanamoto, Takeshi,Anno, Ryoko,Yamada, Kenji,Ryu, Kousuke,Maeda, Ryoko,Aoi, Kazuya,Furuno, Hiroshi. "β-Trifluoromethyl-α-functionalized-vinyl sulfides as a potential synthetic intermediate". scheme or table. p. 2757 - 2765. Retrieved 2009/08/15.