Z-Eda-eda-Z

Base Information

• Chemical Name: Z-Eda-eda-Z
• CAS No.: 160256-75-7
• Molecular Formula: C₂₀H₂₅N₃O₄
• Molecular Weight: 371.436
• European Community (EC) Number: 626-460-8
• DSSTox Substance ID: DTXSID30402452
• Nikkaji Number: J1.822.067I
• Wikidata: Q82205866
• Mol file: 160256-75-7.mol

Synonyms:160256-75-7;Z-EDA-EDA-Z;Dibenzyl (azanediylbis(ethane-2,1-diyl))dicarbamate;benzyl N-[2-[2-(phenylmethoxycarbonylamino)ethylamino]ethyl]carbamate;Dibenzyl 2,2'-iminobis(ethylcarbamate);bis(benzyloxycarbonylaminoethyl)-amine;DIBENZYL 2,2/'-IMINOBIS(ETHYLCARBAMATE);N,N"-Di-Z-diethylenetriamine;N,N-Di-Z-diethylenetriamine;SCHEMBL5019074;DTXSID30402452;DWPBEWIGNADCAX-UHFFFAOYSA-N;MFCD01863761;10-Oxa-2,5,8-triazaundecanoic acid, 9-oxo-11-phenyl-, phenylmethyl ester;AKOS027250981;benzyl n-{2-[(2-{[(benzyloxy)carbonyl]amino}ethyl)amino]ethyl}carbamate;GS-5981;Bis[2-(benzyloxycarbonylamino)-ethyl]-amine;CS-0138207;N,N'-Di-benZyloxycarbonyl-diethylenetriamine;H10602;1,7-Bis(benzyloxycarbonyl)-1,4,7-triazaheptane;2,2'-Iminobis[N-(benzyloxycarbonyl)ethanamine];Dibenzyl(azanediylbis(ethane-2,1-diyl))dicarbamate;J-009704;N,N"-Di-Z-diethylenetriamine, >=97.0% (HPLC)

Chemical Property of Z-Eda-eda-Z

Chemical Property:

• Melting Point: 70-74?°C
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature
• XLogP3: 2.2
• Hydrogen Bond Donor Count: 3
• Hydrogen Bond Acceptor Count: 5
• Rotatable Bond Count: 12
• Exact Mass: 371.18450629
• Heavy Atom Count: 27
• Complexity: 383

Purity/Quality:

99%, ^*data from raw suppliers

Z-Eda-Eda-Z ^*data from reagent suppliers

Safty Information:

• Pictogram(s): 7083538
• Hazard Codes: Xi,N
• Statements: 37/38-41-50
• Safety Statements: 26-39-61

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC=C(C=C1)COC(=O)NCCNCCNC(=O)OCC2=CC=CC=C2
• Uses: Building block to introduce e.g. a protected 2,2'-iminodi(ethylamine) scaffold in libraries.

Technology Process of Z-Eda-eda-Z

There total 9 articles about Z-Eda-eda-Z which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

benzyl cyanoformate (5532-86-5) + 3-azapentane-1,5-diamine (111-40-0,98824-35-2) → N,N''-di-Z-diethylenetriamine (160256-75-7)

Guidance literature:

With triethylamine; In dichloromethane; at -20 - 22 ℃; for 12h;

Reference yield: 87.0%

N-(Benzyloxycarbonyloxy)succinimide (13139-17-8) + 3-azapentane-1,5-diamine (111-40-0,98824-35-2) → N,N''-di-Z-diethylenetriamine (160256-75-7) + {2-[Benzyloxycarbonyl-(2-benzyloxycarbonylamino-ethyl)-amino]-ethyl}-carbamic acid benzyl ester

Guidance literature:

In dichloromethane; at -40 ℃;

DOI:10.1080/00304949809355294

Reference yield: 72.0%

benzyl phenyl carbonate (28170-07-2) + 3-azapentane-1,5-diamine (111-40-0,98824-35-2) → N,N''-di-Z-diethylenetriamine (160256-75-7)

Guidance literature:

In N,N-dimethyl-formamide; at 20 ℃;

DOI:10.1055/s-2002-34859

upstream raw materials:

N-(Benzyloxycarbonyloxy)succinimide

3-azapentane-1,5-diamine

benzyl phenyl carbonate

benzyl cyanoformate

Downstream raw materials:

[2-((2-Benzyloxycarbonylamino-ethyl)-{2-[(1R,2R,3S,5R,6S)-3,5-diazido-2-((2R,3R,4R,5R,6R)-3-azido-6-azidomethyl-4,5-bis-benzyloxy-tetrahydro-pyran-2-yloxy)-6-benzyloxy-cyclohexyloxy]-ethyl}-amino)-ethyl]-carbamic acid benzyl ester

[bis[2-(benzyloxycarbonylamino)ethyl]amino]acetic acid tert-butyl ester

N'-uracil-3-ylaminocarbonylmethyl-N,N''-dicarbobenzoxydiethylenetriamine

4-benzyloxycarbonylamino-5-(bis-(2-benzyloxycarbonylaminoethyl)-amino)-pentanoic acid benzyl ester