tert-butyl (2S)-5-[bis(2-{[(benzyloxy)carbonyl]amino}ethyl)amino]-2-{bis[(tert-butoxy)carbonyl]amino}pentanoate

Base Information

Chemical Name:tert-butyl (2S)-5-[bis(2-{[(benzyloxy)carbonyl]amino}ethyl)amino]-2-{bis[(tert-butoxy)carbonyl]amino}pentanoate
CAS No.:1083175-01-2
Molecular Formula:C₃₉H₅₈N₄O₁₀
Molecular Weight:742.91
Hs Code.:

Synonyms:tert-butyl (2S)-5-[bis(2-{[(benzyloxy)carbonyl]amino}ethyl)amino]-2-{bis[(tert-butoxy)carbonyl]amino}pentanoate

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Chemical Property of tert-butyl (2S)-5-[bis(2-{[(benzyloxy)carbonyl]amino}ethyl)amino]-2-{bis[(tert-butoxy)carbonyl]amino}pentanoate

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Technology Process of tert-butyl (2S)-5-[bis(2-{[(benzyloxy)carbonyl]amino}ethyl)amino]-2-{bis[(tert-butoxy)carbonyl]amino}pentanoate

There total 3 articles about tert-butyl (2S)-5-[bis(2-{[(benzyloxy)carbonyl]amino}ethyl)amino]-2-{bis[(tert-butoxy)carbonyl]amino}pentanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 57.0%

: 129241-89-0
tert-butyl (2S)-2-{bis[(tert-butoxy)carbonyl]amino}-5-oxopentanoate

: 160256-75-7
N,N''-di-Z-diethylenetriamine

: 1083175-01-2
tert-butyl (2S)-5-[bis(2-{[(benzyloxy)carbonyl]amino}ethyl)amino]-2-{bis[(tert-butoxy)carbonyl]amino}pentanoate

Guidance literature:: tert-butyl (2S)-2-{bis[(tert-butoxy)carbonyl]amino}-5-oxopentanoate; N,N''-di-Z-diethylenetriamine; With acetic acid; In dichloromethane; at 0 ℃; for 1h;

With sodium tris(acetoxy)borohydride; In dichloromethane; at 20 ℃;

Reference yield:

: 24277-39-2
N-tert-butoxycarbonyl glutamic acid tert-butyl ester

: 1083175-01-2
tert-butyl (2S)-5-[bis(2-{[(benzyloxy)carbonyl]amino}ethyl)amino]-2-{bis[(tert-butoxy)carbonyl]amino}pentanoate

Guidance literature:: Multi-step reaction with 4 steps

1.1: potassium carbonate / N,N-dimethyl-formamide / 2 h / 20 °C

2.1: dmap; triethylamine / acetonitrile / 2 h / 20 °C

3.1: diisobutylaluminium hydride / diethyl ether; tetrahydrofuran / -78 °C / Inert atmosphere

4.1: acetic acid / dichloromethane / 1 h / 0 °C

4.2: 20 °C

With dmap; diisobutylaluminium hydride; potassium carbonate; acetic acid; triethylamine; In tetrahydrofuran; diethyl ether; dichloromethane; N,N-dimethyl-formamide; acetonitrile;

Reference yield:

: 24424-99-5
di-tert-butyl dicarbonate

: 1083175-01-2
tert-butyl (2S)-5-[bis(2-{[(benzyloxy)carbonyl]amino}ethyl)amino]-2-{bis[(tert-butoxy)carbonyl]amino}pentanoate

Guidance literature:: Multi-step reaction with 3 steps

1.1: dmap; triethylamine / acetonitrile / 2 h / 20 °C

2.1: diisobutylaluminium hydride / diethyl ether; tetrahydrofuran / -78 °C / Inert atmosphere

3.1: acetic acid / dichloromethane / 1 h / 0 °C

3.2: 20 °C

With dmap; diisobutylaluminium hydride; acetic acid; triethylamine; In tetrahydrofuran; diethyl ether; dichloromethane; acetonitrile;