tert-butyl N-(2-fluoro-4-(3-((2-(4-methylpiperidin-1-yl)-6-(trifluoromethyl)pyridin-3-yl)methyl)ureido)benzyl)sulfamoylcarbamate

Base Information

Chemical Name:tert-butyl N-(2-fluoro-4-(3-((2-(4-methylpiperidin-1-yl)-6-(trifluoromethyl)pyridin-3-yl)methyl)ureido)benzyl)sulfamoylcarbamate
CAS No.:1428790-38-8
Molecular Formula:C₂₆H₃₄F₄N₆O₅S
Molecular Weight:618.653
Hs Code.:

Synonyms:tert-butyl N-(2-fluoro-4-(3-((2-(4-methylpiperidin-1-yl)-6-(trifluoromethyl)pyridin-3-yl)methyl)ureido)benzyl)sulfamoylcarbamate

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Chemical Property of tert-butyl N-(2-fluoro-4-(3-((2-(4-methylpiperidin-1-yl)-6-(trifluoromethyl)pyridin-3-yl)methyl)ureido)benzyl)sulfamoylcarbamate

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Technology Process of tert-butyl N-(2-fluoro-4-(3-((2-(4-methylpiperidin-1-yl)-6-(trifluoromethyl)pyridin-3-yl)methyl)ureido)benzyl)sulfamoylcarbamate

There total 7 articles about tert-butyl N-(2-fluoro-4-(3-((2-(4-methylpiperidin-1-yl)-6-(trifluoromethyl)pyridin-3-yl)methyl)ureido)benzyl)sulfamoylcarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

: 935518-29-9
(2-(4-methylpiperidin-1-yl)-6-(trifluoromethyl)pyridin-3-yl)methanamine

: 1402586-22-4
2-(N-(2-fluoro-4-(phenoxycarbonylamino)benzyl)sulfamoyl-carbamoyloxy)-2-methylpropan-1-ylium

: 1428790-38-8
tert-butyl N-(2-fluoro-4-(3-((2-(4-methylpiperidin-1-yl)-6-(trifluoromethyl)pyridin-3-yl)methyl)ureido)benzyl)sulfamoylcarbamate

Guidance literature:: With dmap; In acetonitrile; at 50 ℃;

Reference yield:

: 1402586-10-0
2-(2-fluoro-4-nitrobenzyl)isoindoline-1,3-dione

: 1428790-38-8
tert-butyl N-(2-fluoro-4-(3-((2-(4-methylpiperidin-1-yl)-6-(trifluoromethyl)pyridin-3-yl)methyl)ureido)benzyl)sulfamoylcarbamate

Guidance literature:: Multi-step reaction with 5 steps

1.1: toluene-4-sulfonic acid; hydrazine hydrate / tetrahydrofuran / 6 h / Reflux

2.1: dichloromethane / 0.17 h

2.2: 3.5 h / 23 - 50 °C

3.1: palladium 10% on activated carbon; hydrogen / tetrahydrofuran; ethanol / 6 h / 23 °C

4.1: pyridine / tetrahydrofuran; acetonitrile / 1 h / 0 - 23 °C

5.1: dmap / acetonitrile / 50 °C

With pyridine; dmap; palladium 10% on activated carbon; hydrogen; toluene-4-sulfonic acid; hydrazine hydrate; In tetrahydrofuran; ethanol; dichloromethane; acetonitrile;

Reference yield:

: (2-fluoro-4-nitrophenyl)methanamine

: 1428790-38-8
tert-butyl N-(2-fluoro-4-(3-((2-(4-methylpiperidin-1-yl)-6-(trifluoromethyl)pyridin-3-yl)methyl)ureido)benzyl)sulfamoylcarbamate

Guidance literature:: Multi-step reaction with 4 steps

1.1: dichloromethane / 0.17 h

1.2: 3.5 h / 23 - 50 °C

2.1: palladium 10% on activated carbon; hydrogen / tetrahydrofuran; ethanol / 6 h / 23 °C

3.1: pyridine / tetrahydrofuran; acetonitrile / 1 h / 0 - 23 °C

4.1: dmap / acetonitrile / 50 °C

With pyridine; dmap; palladium 10% on activated carbon; hydrogen; In tetrahydrofuran; ethanol; dichloromethane; acetonitrile;