(2R,3R)-1-methyl-2,3-diphenyl-4-aza-1-azoniabicyclo[2.2.2]octane trifluoromethanesulfonate

Base Information

Chemical Name:(2R,3R)-1-methyl-2,3-diphenyl-4-aza-1-azoniabicyclo[2.2.2]octane trifluoromethanesulfonate
CAS No.:1499076-27-5
Molecular Formula:CF₃O₃S*C₁₉H₂₃N₂
Molecular Weight:428.475
Hs Code.:

Synonyms:(2R,3R)-1-methyl-2,3-diphenyl-4-aza-1-azoniabicyclo[2.2.2]octane trifluoromethanesulfonate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (2R,3R)-1-methyl-2,3-diphenyl-4-aza-1-azoniabicyclo[2.2.2]octane trifluoromethanesulfonate

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Technology Process of (2R,3R)-1-methyl-2,3-diphenyl-4-aza-1-azoniabicyclo[2.2.2]octane trifluoromethanesulfonate

There total 4 articles about (2R,3R)-1-methyl-2,3-diphenyl-4-aza-1-azoniabicyclo[2.2.2]octane trifluoromethanesulfonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: 1499076-22-0
(2R,3R)-2,3-diphenyl-1,4-diazabicyclo[2.2.2]octane

: 333-27-7
methyl trifluoromethanesulfonate

: 1499076-27-5
(2R,3R)-1-methyl-2,3-diphenyl-4-aza-1-azoniabicyclo[2.2.2]octane trifluoromethanesulfonate

Guidance literature:: In diethyl ether; at 0 - 20 ℃; for 3h;

Reference yield:

: 35132-20-8
(R,R)-1,2-diphenylethylenediamine

: 1499076-27-5
(2R,3R)-1-methyl-2,3-diphenyl-4-aza-1-azoniabicyclo[2.2.2]octane trifluoromethanesulfonate

Guidance literature:: Multi-step reaction with 4 steps

1: triethylamine; dmap / dichloromethane / 3 h / 0 - 20 °C

2: borane-THF / tetrahydrofuran / 12 h / 0 °C / Reflux

3: N,N-dimethyl-formamide / 5 h / Reflux

4: diethyl ether / 3 h / 0 °C

With dmap; borane-THF; triethylamine; In tetrahydrofuran; diethyl ether; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1002/anie.201304845

Reference yield:

: 1499076-20-8
N,N'-((1R,2R)-1,2-diphenylethane-1,2-diyl)bis(2-chloroacetamide)

: 1499076-27-5
(2R,3R)-1-methyl-2,3-diphenyl-4-aza-1-azoniabicyclo[2.2.2]octane trifluoromethanesulfonate

Guidance literature:: Multi-step reaction with 3 steps

1: borane-THF / tetrahydrofuran / 12 h / 0 °C / Reflux

2: N,N-dimethyl-formamide / 5 h / Reflux

3: diethyl ether / 3 h / 0 °C

With borane-THF; In tetrahydrofuran; diethyl ether; N,N-dimethyl-formamide;
DOI:10.1002/anie.201304845