15-[(4-Benzyloxycarbonylamino-butyl)-(3-benzyloxycarbonylamino-propyl)-carbamoyl]-pentadecanoic acid

Base Information

• Chemical Name: 15-[(4-Benzyloxycarbonylamino-butyl)-(3-benzyloxycarbonylamino-propyl)-carbamoyl]-pentadecanoic acid
• CAS No.: 177334-75-7
• Molecular Formula: C₃₉H₅₉N₃O₇
• Molecular Weight: 681.913
• Mol file: 177334-75-7.mol

Synonyms:15-[(4-Benzyloxycarbonylamino-butyl)-(3-benzyloxycarbonylamino-propyl)-carbamoyl]-pentadecanoic acid

Chemical Property of 15-[(4-Benzyloxycarbonylamino-butyl)-(3-benzyloxycarbonylamino-propyl)-carbamoyl]-pentadecanoic acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 15-[(4-Benzyloxycarbonylamino-butyl)-(3-benzyloxycarbonylamino-propyl)-carbamoyl]-pentadecanoic acid

There total 7 articles about 15-[(4-Benzyloxycarbonylamino-butyl)-(3-benzyloxycarbonylamino-propyl)-carbamoyl]-pentadecanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 62.0%

thapsic acid (505-54-4) + <3-<<4-(carboxyamino)butyl>amino>propyl>carbamic acid, dibenzyl ester (89965-56-0) → 15-[(4-Benzyloxycarbonylamino-butyl)-(3-benzyloxycarbonylamino-propyl)-carbamoyl]-pentadecanoic acid (177334-75-7)

Guidance literature:

With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; at 20 ℃; for 24h;

DOI:10.1055/s-2003-40195

Reference yield:

15-[(4-Benzyloxycarbonylamino-butyl)-(3-benzyloxycarbonylamino-propyl)-carbamoyl]-pentadecanoic acid methyl ester (177334-74-6) → 15-[(4-Benzyloxycarbonylamino-butyl)-(3-benzyloxycarbonylamino-propyl)-carbamoyl]-pentadecanoic acid (177334-75-7)

Guidance literature:

With sodium hydroxide; In methanol; at 23 ℃; for 24h;

DOI:10.1002/hlca.19960790221

Reference yield:

N-(3-aminopropyl)-1,4-diaminobutane (124-20-9) → 15-[(4-Benzyloxycarbonylamino-butyl)-(3-benzyloxycarbonylamino-propyl)-carbamoyl]-pentadecanoic acid (177334-75-7)

Guidance literature:

Multi-step reaction with 2 steps

1: 95 percent / CH₂Cl₂ / 2 h / 0 °C

2: 62 percent / EDCI; DMAP / CH₂Cl₂ / 24 h / 20 °C

With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane;

DOI:10.1055/s-2003-40195

upstream raw materials:

15-[(4-Benzyloxycarbonylamino-butyl)-(3-benzyloxycarbonylamino-propyl)-carbamoyl]-pentadecanoic acid methyl ester

thapsic acid

<3-<<4-(carboxyamino)butyl>amino>propyl>carbamic acid, dibenzyl ester

N-(3-aminopropyl)-1,4-diaminobutane