N⁴-Anisoyl-P-methyl-5'-O-dimethoxytrityl-2'-deoxycytidyl-(3'5')-N⁶-benzoyl-3'-O-levulinyl-2'-deoxyadenosine

Base Information

• Chemical Name: N⁴-Anisoyl-P-methyl-5'-O-dimethoxytrityl-2'-deoxycytidyl-(3'5')-N⁶-benzoyl-3'-O-levulinyl-2'-deoxyadenosine
• CAS No.: 93134-44-2
• Molecular Formula: C₆₁H₆₁N₈O₁₆P
• Molecular Weight: 1193.17

Synonyms:N⁴-Anisoyl-P-methyl-5'-O-dimethoxytrityl-2'-deoxycytidyl-(3'5')-N⁶-benzoyl-3'-O-levulinyl-2'-deoxyadenosine

Chemical Property of N⁴-Anisoyl-P-methyl-5'-O-dimethoxytrityl-2'-deoxycytidyl-(3'5')-N⁶-benzoyl-3'-O-levulinyl-2'-deoxyadenosine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N⁴-Anisoyl-P-methyl-5'-O-dimethoxytrityl-2'-deoxycytidyl-(3'5')-N⁶-benzoyl-3'-O-levulinyl-2'-deoxyadenosine

There total 4 articles about N⁴-Anisoyl-P-methyl-5'-O-dimethoxytrityl-2'-deoxycytidyl-(3'5')-N⁶-benzoyl-3'-O-levulinyl-2'-deoxyadenosine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

levulinic acid (123-76-2) → N4-Anisoyl-P-methyl-5'-O-dimethoxytrityl-2'-deoxycytidyl-(3'5')-N6-benzoyl-3'-O-levulinyl-2'-deoxyadenosine (93134-44-2)

Guidance literature:

Multi-step reaction with 3 steps

1: 86.6 percent / (N,N-dimethylamino)pyridine, dicyclohexylcarbodiimide / dioxane / 1 h

2: 93 percent / 80 percent acetic acid / 0.5 h

3: 1.) tetrazole 2.) iodine / 1.) acetonitrile, ice bath, 15 min 2.) THF:lutidine:water (2:1:1), 15 min, yield: 77 percent

With 1H-tetrazole; dmap; iodine; acetic acid; dicyclohexyl-carbodiimide; In 1,4-dioxane;

DOI:10.1021/jo00199a032

Reference yield:

N6-benzoyl-5'-O-(4,4'-dimethoxytrityl)-2'-deoxyadenosine (64325-78-6) → N4-Anisoyl-P-methyl-5'-O-dimethoxytrityl-2'-deoxycytidyl-(3'5')-N6-benzoyl-3'-O-levulinyl-2'-deoxyadenosine (93134-44-2)

Guidance literature:

Multi-step reaction with 3 steps

1: 86.6 percent / (N,N-dimethylamino)pyridine, dicyclohexylcarbodiimide / dioxane / 1 h

2: 93 percent / 80 percent acetic acid / 0.5 h

3: 1.) tetrazole 2.) iodine / 1.) acetonitrile, ice bath, 15 min 2.) THF:lutidine:water (2:1:1), 15 min, yield: 77 percent

With 1H-tetrazole; dmap; iodine; acetic acid; dicyclohexyl-carbodiimide; In 1,4-dioxane;

DOI:10.1021/jo00199a032

Reference yield:

5'-O-(4,4'-dimethoxytrityl)-N6-benzoyl-3'-O-levulinoyl-2'-deoxyadenosine (93134-36-2) → N4-Anisoyl-P-methyl-5'-O-dimethoxytrityl-2'-deoxycytidyl-(3'5')-N6-benzoyl-3'-O-levulinyl-2'-deoxyadenosine (93134-44-2)

Guidance literature:

Multi-step reaction with 2 steps

1: 93 percent / 80 percent acetic acid / 0.5 h

2: 1.) tetrazole 2.) iodine / 1.) acetonitrile, ice bath, 15 min 2.) THF:lutidine:water (2:1:1), 15 min, yield: 77 percent

With 1H-tetrazole; iodine; acetic acid;

DOI:10.1021/jo00199a032

upstream raw materials:

N-benzoyl-3'-O-levulinoyl-2'-deoxy-β-D-adenosine

3'-O-<(N,N-Dimethylamino)methoxyphosphino>-N⁶-anisoyl-5'-O-(dimethoxytrityl)-2'-deoxycytidine

5'-O-(4,4'-dimethoxytrityl)-N⁶-benzoyl-3'-O-levulinoyl-2'-deoxyadenosine

levulinic acid

Downstream raw materials:

N⁴-Anisoyl-P-methyl-5'-O-dimethoxytrityl-2'-deoxycytidylyl-(3'5')-N⁶-benzoyl-2'-deoxyadenosine

N⁶-Benzoyl-P-methyl-5'-O-dimethoxytrityl-2'-deoxyadenosyl-(3'5')-N⁴-benzoyl-2'-deoxycytidine

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 93134-44-2 N⁴-Anisoyl-P-methyl-5'-O-dimethoxytrityl-2'-deoxycytidyl-(3'5')-N⁶-benzoyl-3'-O-levulinyl-2'-deoxyadenosine

Send

Send

Metric Ton KG G Pound L ML

Send

Send