5-acetyl-6-methyl-4-(4-chlorophenyl)-3-cyano-3,4-dihydro-2<1H>pyridinethione

Base Information

• Chemical Name: 5-acetyl-6-methyl-4-(4-chlorophenyl)-3-cyano-3,4-dihydro-2<1H>pyridinethione
• CAS No.: 103868-26-4
• Molecular Formula: C₁₅H₁₃ClN₂OS
• Molecular Weight: 304.8
• Mol file: 103868-26-4.mol

Synonyms:5-acetyl-6-methyl-4-(4-chlorophenyl)-3-cyano-3,4-dihydro-2<1H>pyridinethione

Chemical Property of 5-acetyl-6-methyl-4-(4-chlorophenyl)-3-cyano-3,4-dihydro-2<1H>pyridinethione

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 5-acetyl-6-methyl-4-(4-chlorophenyl)-3-cyano-3,4-dihydro-2<1H>pyridinethione

There total 2 articles about 5-acetyl-6-methyl-4-(4-chlorophenyl)-3-cyano-3,4-dihydro-2<1H>pyridinethione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

5-Acetyl-4-(4-chloro-phenyl)-2-mercapto-6-methyl-1,4-dihydro-pyridine-3-carbonitrile; compound with piperidine (103868-17-3) → 5-acetyl-6-methyl-4-(4-chlorophenyl)-3-cyano-3,4-dihydro-2<1H>pyridinethione (103868-26-4)

Guidance literature:

With hydrogenchloride; In ethanol;

DOI:10.1007/BF00953940

Reference yield:

2-cyano-3-(4-chlorophenyl)-prop-2-enethioamide (39145-33-0) + acetylacetone (123-54-6,81235-32-7) → 5-acetyl-6-methyl-4-(4-chlorophenyl)-3-cyano-2<1H>pyridinethione (103868-29-7) + 5-acetyl-6-methyl-4-(4-chlorophenyl)-3-cyano-3,4-dihydro-2<1H>pyridinethione (103868-26-4)

Guidance literature:

With triethylamine; In ethanol; for 5h; Heating;

DOI:10.1515/znb-1999-0517

Reference yield: 73.0%

5-acetyl-6-methyl-4-(4-chlorophenyl)-3-cyano-3,4-dihydro-2<1H>pyridinethione (103868-26-4) → Sodium; 5-acetyl-4-(4-chloro-phenyl)-3-cyano-6-methyl-1,4-dihydro-pyridine-2-thiolate (116736-49-3)

Guidance literature:

With sodium ethanolate; for 0.333333h; Ambient temperature;

DOI:10.1007/BF00769648

upstream raw materials:

5-Acetyl-4-(4-chloro-phenyl)-2-mercapto-6-methyl-1,4-dihydro-pyridine-3-carbonitrile; compound with piperidine

2-cyano-3-(4-chlorophenyl)-prop-2-enethioamide

acetylacetone

Downstream raw materials:

Sodium; 5-acetyl-4-(4-chloro-phenyl)-3-cyano-6-methyl-1,4-dihydro-pyridine-2-thiolate

5-acetyl-4-(4-chloro-phenyl)-6-methyl-2-(2-oxo-propylsulfanyl)-nicotinonitrile

1-[2-acetyl-3-amino-4-(4-chloro-phenyl)-6-methyl-thieno[2,3-b]pyridin-5-yl]-ethanone

5-acetyl-3-amino-4-(4-chloro-phenyl)-6-methyl-thieno[2,3-b]pyridine-2-carboxylic acid ethyl ester