5-hydroxy-6-(4-methoxy-benzyloxy)-hex-2-ynoic acid ethyl ester

Base Information

• Chemical Name: 5-hydroxy-6-(4-methoxy-benzyloxy)-hex-2-ynoic acid ethyl ester
• CAS No.: 319456-40-1
• Molecular Formula: C₁₆H₂₀O₅
• Molecular Weight: 292.332
• Mol file: 319456-40-1.mol

Synonyms:5-hydroxy-6-(4-methoxy-benzyloxy)-hex-2-ynoic acid ethyl ester

Chemical Property of 5-hydroxy-6-(4-methoxy-benzyloxy)-hex-2-ynoic acid ethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 5-hydroxy-6-(4-methoxy-benzyloxy)-hex-2-ynoic acid ethyl ester

There total 1 articles about 5-hydroxy-6-(4-methoxy-benzyloxy)-hex-2-ynoic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

2-((4-methoxybenzyloxy)methyl)oxirane (108836-41-5) + propynoic acid ethyl ester (623-47-2) → 5-hydroxy-6-(4-methoxy-benzyloxy)-hex-2-ynoic acid ethyl ester (319456-40-1)

Guidance literature:

propynoic acid ethyl ester; With n-butyllithium; In tetrahydrofuran; at -78 ℃; for 1h;

2-((4-methoxybenzyloxy)methyl)oxirane; With boron trifluoride diethyl etherate; In tetrahydrofuran; at -78 - 0 ℃; Further stages.;

DOI:10.1021/ja0022268

Reference yield: 86.0%

silylacetylene (1066-27-9) + 5-hydroxy-6-(4-methoxy-benzyloxy)-hex-2-ynoic acid ethyl ester (319456-40-1) → C18H22O5

Guidance literature:

With tetrabutyl ammonium fluoride; acetic acid; In tetrahydrofuran; at 20 ℃; for 48h; Inert atmosphere;

DOI:10.1002/chem.201002898

Reference yield: 69.0%

3,3-Dimethylbut-1-yne (917-92-0) + 5-hydroxy-6-(4-methoxy-benzyloxy)-hex-2-ynoic acid ethyl ester (319456-40-1) → C22H30O5

Guidance literature:

With palladium(II) trifluoroacetate; palladium diacetate; tris(2,6-dimethoxyphenyl)phosphine; In benzene; at 20 ℃; for 216h; Inert atmosphere;

DOI:10.1002/chem.201002898

upstream raw materials:

2-((4-methoxybenzyloxy)methyl)oxirane

propynoic acid ethyl ester