methyl 4-(1-(5-chloro-2-(3-((4-fluoro-2-methylphenyl)amino)azetidin-1-yl)nicotinamido)cyclopropyl)benzoate

Base Information

Chemical Name:methyl 4-(1-(5-chloro-2-(3-((4-fluoro-2-methylphenyl)amino)azetidin-1-yl)nicotinamido)cyclopropyl)benzoate
CAS No.:1380754-92-6
Molecular Formula:C₂₇H₂₆ClFN₄O₃
Molecular Weight:508.98
Hs Code.:

Synonyms:methyl 4-(1-(5-chloro-2-(3-((4-fluoro-2-methylphenyl)amino)azetidin-1-yl)nicotinamido)cyclopropyl)benzoate

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Chemical Property of methyl 4-(1-(5-chloro-2-(3-((4-fluoro-2-methylphenyl)amino)azetidin-1-yl)nicotinamido)cyclopropyl)benzoate

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Technology Process of methyl 4-(1-(5-chloro-2-(3-((4-fluoro-2-methylphenyl)amino)azetidin-1-yl)nicotinamido)cyclopropyl)benzoate

There total 9 articles about methyl 4-(1-(5-chloro-2-(3-((4-fluoro-2-methylphenyl)amino)azetidin-1-yl)nicotinamido)cyclopropyl)benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1380753-04-7
N-(4-fluoro-2-methylphenyl)azetidin-3-amine

: 1380753-67-2
methyl 4-(1-(2,5-dichloronicotinamido)cyclopropyl)benzoate

: 1380754-92-6
methyl 4-(1-(5-chloro-2-(3-((4-fluoro-2-methylphenyl)amino)azetidin-1-yl)nicotinamido)cyclopropyl)benzoate

Guidance literature:: With sodium carbonate; triethylamine; In tetrahydrofuran; methanol; at 75 ℃; for 24h;

Reference yield:

: 345965-52-8
1-(4-bromophenyl)cyclopropanecarboxylic acid

: 1380754-92-6
methyl 4-(1-(5-chloro-2-(3-((4-fluoro-2-methylphenyl)amino)azetidin-1-yl)nicotinamido)cyclopropyl)benzoate

Guidance literature:: Multi-step reaction with 5 steps

1: N-ethyl-N,N-diisopropylamine; diphenyl phosphoryl azide / toluene / 5 h / Molecular sieve; Reflux

2: triethylamine; 1,3-bis-(diphenylphosphino)propane / palladium diacetate / N,N-dimethyl-formamide; methanol / 48 h / 80 °C / 30003 Torr

3: hydrogenchloride / ethyl acetate / 20 °C

4: triethylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; 1-hydroxy-1H-benzotriazol hydrate / N,N-dimethyl-formamide / 1 h / 20 °C

5: triethylamine; sodium carbonate / tetrahydrofuran; methanol / 24 h / 75 °C

With hydrogenchloride; diphenyl phosphoryl azide; 1-hydroxy-1H-benzotriazol hydrate; 1,3-bis-(diphenylphosphino)propane; sodium carbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; N-ethyl-N,N-diisopropylamine; palladium diacetate; In tetrahydrofuran; methanol; ethyl acetate; N,N-dimethyl-formamide; toluene;

Reference yield:

: 360773-84-8
tert-butyl [1-(4-bromophenyl)-cyclopropyl]-carbamate

: 1380754-92-6
methyl 4-(1-(5-chloro-2-(3-((4-fluoro-2-methylphenyl)amino)azetidin-1-yl)nicotinamido)cyclopropyl)benzoate

Guidance literature:: Multi-step reaction with 4 steps

1: triethylamine; 1,3-bis-(diphenylphosphino)propane / palladium diacetate / N,N-dimethyl-formamide; methanol / 48 h / 80 °C / 30003 Torr

2: hydrogenchloride / ethyl acetate / 20 °C

3: triethylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; 1-hydroxy-1H-benzotriazol hydrate / N,N-dimethyl-formamide / 1 h / 20 °C

4: triethylamine; sodium carbonate / tetrahydrofuran; methanol / 24 h / 75 °C

With hydrogenchloride; 1-hydroxy-1H-benzotriazol hydrate; 1,3-bis-(diphenylphosphino)propane; sodium carbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; palladium diacetate; In tetrahydrofuran; methanol; ethyl acetate; N,N-dimethyl-formamide;