methyl 4-(1-(2,5-dichloronicotinamido)cyclopropyl)benzoate

Base Information

Chemical Name:methyl 4-(1-(2,5-dichloronicotinamido)cyclopropyl)benzoate
CAS No.:1380753-67-2
Molecular Formula:C₁₇H₁₄Cl₂N₂O₃
Molecular Weight:365.216
Hs Code.:

Synonyms:methyl 4-(1-(2,5-dichloronicotinamido)cyclopropyl)benzoate

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Chemical Property of methyl 4-(1-(2,5-dichloronicotinamido)cyclopropyl)benzoate

Chemical Property:

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Technology Process of methyl 4-(1-(2,5-dichloronicotinamido)cyclopropyl)benzoate

There total 6 articles about methyl 4-(1-(2,5-dichloronicotinamido)cyclopropyl)benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1014645-87-4
methyl 4-(1-aminocyclopropyl)benzoate hydrochloride

: 59782-85-3
2,5-dichloronicotinic acid

: 1380753-67-2
methyl 4-(1-(2,5-dichloronicotinamido)cyclopropyl)benzoate

Guidance literature:: With 1-hydroxy-1H-benzotriazol hydrate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In N,N-dimethyl-formamide; at 20 ℃; for 1h;

Reference yield:

: 345965-52-8
1-(4-bromophenyl)cyclopropanecarboxylic acid

: 1380753-67-2
methyl 4-(1-(2,5-dichloronicotinamido)cyclopropyl)benzoate

Guidance literature:: Multi-step reaction with 4 steps

1: N-ethyl-N,N-diisopropylamine; diphenyl phosphoryl azide / toluene / 5 h / Molecular sieve; Reflux

2: triethylamine; 1,3-bis-(diphenylphosphino)propane / palladium diacetate / N,N-dimethyl-formamide; methanol / 48 h / 80 °C / 30003 Torr

3: hydrogenchloride / ethyl acetate / 20 °C

4: triethylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; 1-hydroxy-1H-benzotriazol hydrate / N,N-dimethyl-formamide / 1 h / 20 °C

With hydrogenchloride; diphenyl phosphoryl azide; 1-hydroxy-1H-benzotriazol hydrate; 1,3-bis-(diphenylphosphino)propane; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; N-ethyl-N,N-diisopropylamine; palladium diacetate; In methanol; ethyl acetate; N,N-dimethyl-formamide; toluene;

Reference yield:

: 360773-84-8
tert-butyl [1-(4-bromophenyl)-cyclopropyl]-carbamate

: 1380753-67-2
methyl 4-(1-(2,5-dichloronicotinamido)cyclopropyl)benzoate

Guidance literature:: Multi-step reaction with 3 steps

1: triethylamine; 1,3-bis-(diphenylphosphino)propane / palladium diacetate / N,N-dimethyl-formamide; methanol / 48 h / 80 °C / 30003 Torr

2: hydrogenchloride / ethyl acetate / 20 °C

3: triethylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; 1-hydroxy-1H-benzotriazol hydrate / N,N-dimethyl-formamide / 1 h / 20 °C

With hydrogenchloride; 1-hydroxy-1H-benzotriazol hydrate; 1,3-bis-(diphenylphosphino)propane; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; palladium diacetate; In methanol; ethyl acetate; N,N-dimethyl-formamide;