4-(3-chloro-4-isopropoxyphenylamino)-1-benzyl-5-hydroxycarbonylpyridine-2(1H)-one

Base Information

Chemical Name:4-(3-chloro-4-isopropoxyphenylamino)-1-benzyl-5-hydroxycarbonylpyridine-2(1H)-one
CAS No.:1359815-35-2
Molecular Formula:C₂₂H₂₁ClN₂O₄
Molecular Weight:412.873
Hs Code.:

Synonyms:4-(3-chloro-4-isopropoxyphenylamino)-1-benzyl-5-hydroxycarbonylpyridine-2(1H)-one

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Chemical Property of 4-(3-chloro-4-isopropoxyphenylamino)-1-benzyl-5-hydroxycarbonylpyridine-2(1H)-one

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Technology Process of 4-(3-chloro-4-isopropoxyphenylamino)-1-benzyl-5-hydroxycarbonylpyridine-2(1H)-one

There total 5 articles about 4-(3-chloro-4-isopropoxyphenylamino)-1-benzyl-5-hydroxycarbonylpyridine-2(1H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: 1359815-29-4
4-(3-chloro-4-isopropoxyphenylamino)-1-benzyl-5-(ethoxycarbonyl)pyridine-2(1H)-one

: 1359815-35-2
4-(3-chloro-4-isopropoxyphenylamino)-1-benzyl-5-hydroxycarbonylpyridine-2(1H)-one

Guidance literature:: With lithium hydroxide monohydrate; water; In tetrahydrofuran; ethanol; at 50 ℃; for 15h;

Reference yield:

: 105-50-0
diethyl 1,3-acetonedicarboxylate

: 1359815-35-2
4-(3-chloro-4-isopropoxyphenylamino)-1-benzyl-5-hydroxycarbonylpyridine-2(1H)-one

Guidance literature:: Multi-step reaction with 4 steps

1.1: orthoformic acid triethyl ester; acetic anhydride / 15 h / Reflux

1.2: 2.33 h / 20 - 90 °C

2.1: trichlorophosphate / 1 h / 90 °C

3.1: 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; palladium diacetate; caesium carbonate / 1,4-dioxane / 1 h / Reflux

4.1: lithium hydroxide monohydrate; water / tetrahydrofuran; ethanol / 15 h / 50 °C

With lithium hydroxide monohydrate; water; palladium diacetate; acetic anhydride; caesium carbonate; orthoformic acid triethyl ester; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; trichlorophosphate; In tetrahydrofuran; 1,4-dioxane; ethanol;

Reference yield:

: 100-46-9
benzylamine

: 1359815-35-2
4-(3-chloro-4-isopropoxyphenylamino)-1-benzyl-5-hydroxycarbonylpyridine-2(1H)-one

Guidance literature:: Multi-step reaction with 4 steps

1.1: orthoformic acid triethyl ester; acetic anhydride / 15 h / Reflux

1.2: 2.33 h / 20 - 90 °C

2.1: trichlorophosphate / 1 h / 90 °C

3.1: 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; palladium diacetate; caesium carbonate / 1,4-dioxane / 1 h / Reflux

4.1: lithium hydroxide monohydrate; water / tetrahydrofuran; ethanol / 15 h / 50 °C

With lithium hydroxide monohydrate; water; palladium diacetate; acetic anhydride; caesium carbonate; orthoformic acid triethyl ester; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; trichlorophosphate; In tetrahydrofuran; 1,4-dioxane; ethanol;