(S)-benzyl (1-(tert-butylamino)-1-oxo-3-phenylpropan-2-yl)carbamate

Base Information

• Chemical Name: (S)-benzyl (1-(tert-butylamino)-1-oxo-3-phenylpropan-2-yl)carbamate
• CAS No.: 17186-44-6
• Molecular Formula: C₂₁H₂₆N₂O₃
• Molecular Weight: 354.449
• Mol file: 17186-44-6.mol

Synonyms:(S)-benzyl (1-(tert-butylamino)-1-oxo-3-phenylpropan-2-yl)carbamate

Chemical Property of (S)-benzyl (1-(tert-butylamino)-1-oxo-3-phenylpropan-2-yl)carbamate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (S)-benzyl (1-(tert-butylamino)-1-oxo-3-phenylpropan-2-yl)carbamate

There total 5 articles about (S)-benzyl (1-(tert-butylamino)-1-oxo-3-phenylpropan-2-yl)carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

N-Cbz-L-Phe (1161-13-3) + tert-butylamine (75-64-9) → (S)-benzyl (1-(tert-butylamino)-1-oxo-3-phenylpropan-2-yl)carbamate (17186-44-6)

Guidance literature:

With 4-methyl-morpholine; 1-hydroxy-7-aza-benzotriazole; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; for 16h; Inert atmosphere;

DOI:10.1039/c4cc03261f

Reference yield:

N-tert-butylacetamide (762-84-5) + benzyl [(2S)-1-amino-1-oxo-3-phenylpropan-2-yl]carbamate (5241-56-5,17324-88-8,53562-23-5,4801-80-3) → (S)-benzyl (1-(tert-butylamino)-1-oxo-3-phenylpropan-2-yl)carbamate (17186-44-6)

Guidance literature:

With perchloric acid;

Reference yield:

N-Cbz-L-Phe (1161-13-3) + tert-butylamine (75-64-9) + isobutyl chloroformate (543-27-1) → (S)-benzyl (1-(tert-butylamino)-1-oxo-3-phenylpropan-2-yl)carbamate (17186-44-6)

Guidance literature:

With N-ethylmorpholine;; sodium hydrogencarbonate; In hexane; water; ethyl acetate;

upstream raw materials:

N-tert-butylacetamide

benzyl [(2S)-1-amino-1-oxo-3-phenylpropan-2-yl]carbamate

N-Cbz-L-Phe

tert-butylamine

Downstream raw materials:

(S)-2-amino-N-(tert-butyl)-3-phenylpropanamide

benzyl 3(S)-(t-butylcarbamoyl)-1,2,3,4-tetrahydro-2-isoquinolinecarboxylate