1-[2-(dimethylamino)-2-oxoethyl]-5-(4-fluorophenyl)-4-oxo-1,4-dihydropyridine-3-carboxylic acid

Base Information

Chemical Name:1-[2-(dimethylamino)-2-oxoethyl]-5-(4-fluorophenyl)-4-oxo-1,4-dihydropyridine-3-carboxylic acid
CAS No.:1449300-94-0
Molecular Formula:C₁₆H₁₅FN₂O₄
Molecular Weight:318.305
Hs Code.:

Synonyms:1-[2-(dimethylamino)-2-oxoethyl]-5-(4-fluorophenyl)-4-oxo-1,4-dihydropyridine-3-carboxylic acid

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Chemical Property of 1-[2-(dimethylamino)-2-oxoethyl]-5-(4-fluorophenyl)-4-oxo-1,4-dihydropyridine-3-carboxylic acid

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Technology Process of 1-[2-(dimethylamino)-2-oxoethyl]-5-(4-fluorophenyl)-4-oxo-1,4-dihydropyridine-3-carboxylic acid

There total 6 articles about 1-[2-(dimethylamino)-2-oxoethyl]-5-(4-fluorophenyl)-4-oxo-1,4-dihydropyridine-3-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

: ethyl 1-(2-(dimethylamino)-2-oxoethyl)-5-(4-fluorophenyl)-4-oxo-1,4-dihydropyridine-3-carboxylate

: 1449300-94-0
1-[2-(dimethylamino)-2-oxoethyl]-5-(4-fluorophenyl)-4-oxo-1,4-dihydropyridine-3-carboxylic acid

Guidance literature:: With sodium hydroxide; In methanol; water; at 20 ℃; for 1h;
DOI:10.1016/j.ejmech.2021.113497

Reference yield:

: 459-04-1
4-Fluorophenylacetyl chloride

: 1449300-94-0
1-[2-(dimethylamino)-2-oxoethyl]-5-(4-fluorophenyl)-4-oxo-1,4-dihydropyridine-3-carboxylic acid

Guidance literature:: Multi-step reaction with 4 steps

1.1: pyridine / dichloromethane / 5 h / 0 - 20 °C / Inert atmosphere

1.2: 4 h / 80 °C / Inert atmosphere

2.1: toluene / 5 h / 100 °C

2.2: 5 h / 60 °C

3.1: potassium carbonate / N,N-dimethyl-formamide / 3 h / 80 °C

4.1: sodium hydroxide / water; methanol / 1 h / 20 °C

With pyridine; potassium carbonate; sodium hydroxide; In methanol; dichloromethane; water; N,N-dimethyl-formamide; toluene;
DOI:10.1016/j.ejmech.2021.113497

Reference yield:

: 405-50-5
p-Fluorophenylacetic acid

: 1449300-94-0
1-[2-(dimethylamino)-2-oxoethyl]-5-(4-fluorophenyl)-4-oxo-1,4-dihydropyridine-3-carboxylic acid

Guidance literature:: Multi-step reaction with 5 steps

1.1: oxalyl dichloride; N,N-dimethyl-formamide / N,N-dimethyl-formamide / 6 h / 0 - 20 °C / Inert atmosphere

2.1: pyridine / dichloromethane / 5 h / 0 - 20 °C / Inert atmosphere

2.2: 4 h / 80 °C / Inert atmosphere

3.1: toluene / 5 h / 100 °C

3.2: 5 h / 60 °C

4.1: potassium carbonate / N,N-dimethyl-formamide / 3 h / 80 °C

5.1: sodium hydroxide / water; methanol / 1 h / 20 °C

With pyridine; oxalyl dichloride; potassium carbonate; N,N-dimethyl-formamide; sodium hydroxide; In methanol; dichloromethane; water; N,N-dimethyl-formamide; toluene;
DOI:10.1016/j.ejmech.2021.113497