Phosphoric acid 2-chloro-phenyl ester (2R,3R,4S,5R)-4-[(4-methoxy-phenyl)-diphenyl-methoxy]-5-(6-{[(4-methoxy-phenyl)-diphenyl-methyl]-amino}-purin-9-yl)-3-(4-methoxy-tetrahydro-pyran-4-yloxy)-tetrahydro-furan-2-ylmethyl ester; compound with triethyl-amine

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Chemical Name:Phosphoric acid 2-chloro-phenyl ester (2R,3R,4S,5R)-4-[(4-methoxy-phenyl)-diphenyl-methoxy]-5-(6-{[(4-methoxy-phenyl)-diphenyl-methyl]-amino}-purin-9-yl)-3-(4-methoxy-tetrahydro-pyran-4-yloxy)-tetrahydro-furan-2-ylmethyl ester; compound with triethyl-amine
CAS No.:115561-38-1
Molecular Formula:C₆H₁₅N*C₆₂H₅₉ClN₅O₁₁P
Molecular Weight:1217.8
Hs Code.:

Phosphoric acid 2-chloro-phenyl ester (2R,3R,4S,5R)-4-[(4-methoxy-phenyl)-diphenyl-methoxy]-5-(6-{[(4-methoxy-phenyl)-diphenyl-methyl]-amino}-purin-9-yl)-3-(4-methoxy-tetrahydro-pyran-4-yloxy)-tetrahydro-furan-2-ylmethyl ester; compound with triethyl-amine

Synonyms:Phosphoric acid 2-chloro-phenyl ester (2R,3R,4S,5R)-4-[(4-methoxy-phenyl)-diphenyl-methoxy]-5-(6-{[(4-methoxy-phenyl)-diphenyl-methyl]-amino}-purin-9-yl)-3-(4-methoxy-tetrahydro-pyran-4-yloxy)-tetrahydro-furan-2-ylmethyl ester; compound with triethyl-amine

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Chemical Property of Phosphoric acid 2-chloro-phenyl ester (2R,3R,4S,5R)-4-[(4-methoxy-phenyl)-diphenyl-methoxy]-5-(6-{[(4-methoxy-phenyl)-diphenyl-methyl]-amino}-purin-9-yl)-3-(4-methoxy-tetrahydro-pyran-4-yloxy)-tetrahydro-furan-2-ylmethyl ester; compound with triethyl-amine

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Technology Process of Phosphoric acid 2-chloro-phenyl ester (2R,3R,4S,5R)-4-[(4-methoxy-phenyl)-diphenyl-methoxy]-5-(6-{[(4-methoxy-phenyl)-diphenyl-methyl]-amino}-purin-9-yl)-3-(4-methoxy-tetrahydro-pyran-4-yloxy)-tetrahydro-furan-2-ylmethyl ester; compound with triethyl-amine

There total 9 articles about Phosphoric acid 2-chloro-phenyl ester (2R,3R,4S,5R)-4-[(4-methoxy-phenyl)-diphenyl-methoxy]-5-(6-{[(4-methoxy-phenyl)-diphenyl-methyl]-amino}-purin-9-yl)-3-(4-methoxy-tetrahydro-pyran-4-yloxy)-tetrahydro-furan-2-ylmethyl ester; compound with triethyl-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

: 72351-28-1
2-chlorophenyl phosphordi(1H-1-[1,2,4]triazolide)

: 121-44-8
triethylamine

: 115561-36-9
N⁶-(4-monomethoxytrityl)-9-<2-O-(4-monomethoxytrityl)-3-O-(methoxytetrahydropyranyl)-β-D-arabinofuranosyl>adenine

: 115561-38-1
Phosphoric acid 2-chloro-phenyl ester (2R,3R,4S,5R)-4-[(4-methoxy-phenyl)-diphenyl-methoxy]-5-(6-{[(4-methoxy-phenyl)-diphenyl-methyl]-amino}-purin-9-yl)-3-(4-methoxy-tetrahydro-pyran-4-yloxy)-tetrahydro-furan-2-ylmethyl ester; compound with triethyl-amine

Guidance literature:: In pyridine; water; acetonitrile;
DOI:10.1021/jm00118a006

Reference yield:

: 17327-22-9
4-methoxy-2,6-dihydropyran

: 115561-38-1
Phosphoric acid 2-chloro-phenyl ester (2R,3R,4S,5R)-4-[(4-methoxy-phenyl)-diphenyl-methoxy]-5-(6-{[(4-methoxy-phenyl)-diphenyl-methyl]-amino}-purin-9-yl)-3-(4-methoxy-tetrahydro-pyran-4-yloxy)-tetrahydro-furan-2-ylmethyl ester; compound with triethyl-amine

Guidance literature:: Multi-step reaction with 3 steps

1: p-toluenesulfonic acid monohydrate / dioxane / 8.5 h / Ambient temperature

2: 89 percent / tetra-n-butylammonuim fluoride / tetrahydrofuran / 1.5 h / Ambient temperature

3: 89 percent / acetonitrile; pyridine; H₂O

With tetrabutyl ammonium fluoride; toluene-4-sulfonic acid; In tetrahydrofuran; 1,4-dioxane; pyridine; water; acetonitrile;
DOI:10.1021/jm00118a006

Reference yield:

: 87792-02-7
9-[3',5'-O-(1,1,3,3-tetraisopropyldisiloxane-1,3-diyl)-1-β-D-arabinofuranosyl]adenine

: 115561-38-1
Phosphoric acid 2-chloro-phenyl ester (2R,3R,4S,5R)-4-[(4-methoxy-phenyl)-diphenyl-methoxy]-5-(6-{[(4-methoxy-phenyl)-diphenyl-methyl]-amino}-purin-9-yl)-3-(4-methoxy-tetrahydro-pyran-4-yloxy)-tetrahydro-furan-2-ylmethyl ester; compound with triethyl-amine

Guidance literature:: Multi-step reaction with 6 steps

1: pyridine / 72 h / 65 °C

2: 72 percent / KF, Et₄NBr / acetonitrile / 1 h / 50 °C

3: 90 percent / pyridine / 5 h / Ambient temperature

4: p-toluenesulfonic acid monohydrate / dioxane / 8.5 h / Ambient temperature

5: 89 percent / tetra-n-butylammonuim fluoride / tetrahydrofuran / 1.5 h / Ambient temperature

6: 89 percent / acetonitrile; pyridine; H₂O

With potassium fluoride; tetraethylammonium bromide; tetrabutyl ammonium fluoride; toluene-4-sulfonic acid; In tetrahydrofuran; 1,4-dioxane; pyridine; water; acetonitrile;
DOI:10.1021/jm00118a006