Propargyl-PEG6-amine

Base Information

Chemical Name:Propargyl-PEG6-amine
CAS No.:1198080-04-4
Molecular Formula:C₁₅H₂₉NO₆
Molecular Weight:319.398
Hs Code.:
Mol file:1198080-04-4.mol

Synonyms:ω-propynyl-3,6,9,12,15,18-hexaoxahenicos-1-amine

Suppliers and Price of Propargyl-PEG6-amine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
Propargyl-PEG6-amine
5mg
$ 45.00

purepeg
HC≡C-CH2-PEG6-NH2 min.97%
250 mg
$ 250.00

BroadPharm
Propargyl-PEG6-amine 98%
250 MG
$ 185.00

Activate Scientific
Propargyl-PEG6-NH2 95+%
1 g
$ 631.00

Acrotein
Propargyl-PEG6-NH2 97%
1g
$ 495.00

Total 12 raw suppliers

Chemical Property of Propargyl-PEG6-amine

Chemical Property:

Boiling Point:401.8±40.0 °C(Predicted)
PKA:8.74±0.10(Predicted)
Density:1.058±0.06 g/cm3(Predicted)
Solubility.:Soluble in Water, DMSO, DCM, DMF

Purity/Quality:

98%,99%, ^*data from raw suppliers

Propargyl-PEG6-amine ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Description Propargyl-PEG6-amine is a crosslinker with a hydrophilic PEG spacer which can increase the hydrophilicity of the molecule in aqueous environment. The amine group is reactive with carboxylic acids, activated NHS esters, carbonyls (ketone, aldehyde) etc. The propargyl group can react with azide-bearing compounds or biomolecules via copper catalyzed azide-alkyne Click Chemistry.

Technology Process of Propargyl-PEG6-amine

There total 6 articles about Propargyl-PEG6-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: 1422540-95-1
C₂₃H₃₁NO₈

: 1198080-04-4,956348-61-1
ω-propynyl-3,6,9,12,15,18-hexaoxahenicos-1-amine

Guidance literature:: With hydrazine; In ethanol; at 60 ℃; for 3h;
DOI:10.1039/c2ob26968f

Reference yield: 25.0%

: 1198080-03-3
1-azido-3,6,9,12,15,18-hexaoxahenicos-20-yne

: 1198080-04-4,956348-61-1
ω-propynyl-3,6,9,12,15,18-hexaoxahenicos-1-amine

Guidance literature:: With water; triphenylphosphine; In tetrahydrofuran; for 12h; Inert atmosphere;
DOI:10.1021/ja906844e

Reference yield:

: 2615-15-8
pentaethylene glycol

: 1198080-04-4,956348-61-1
ω-propynyl-3,6,9,12,15,18-hexaoxahenicos-1-amine

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium hydride / tetrahydrofuran / 20 °C

1.2: 16 h / 20 - 60 °C

2.1: triethylamine / dichloromethane / 4 h / 0 - 20 °C

3.1: N,N-dimethyl-formamide / 15 h / 110 °C

4.1: hydrazine / ethanol / 3 h / 60 °C

With sodium hydride; triethylamine; hydrazine; In tetrahydrofuran; ethanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1039/c2ob26968f