4-[4-(3,5-dichlorophenyl)-3-trifluoromethylpyrazol-1-yl]-N-(2,2,2-trifluoroethyl)-2-trifluoromethylbenzamide

Base Information

Chemical Name:4-[4-(3,5-dichlorophenyl)-3-trifluoromethylpyrazol-1-yl]-N-(2,2,2-trifluoroethyl)-2-trifluoromethylbenzamide
CAS No.:1208342-05-5
Molecular Formula:C₂₀H₁₀Cl₂F₉N₃O
Molecular Weight:550.211
Hs Code.:

Synonyms:4-[4-(3,5-dichlorophenyl)-3-trifluoromethylpyrazol-1-yl]-N-(2,2,2-trifluoroethyl)-2-trifluoromethylbenzamide

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Chemical Property of 4-[4-(3,5-dichlorophenyl)-3-trifluoromethylpyrazol-1-yl]-N-(2,2,2-trifluoroethyl)-2-trifluoromethylbenzamide

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Technology Process of 4-[4-(3,5-dichlorophenyl)-3-trifluoromethylpyrazol-1-yl]-N-(2,2,2-trifluoroethyl)-2-trifluoromethylbenzamide

There total 4 articles about 4-[4-(3,5-dichlorophenyl)-3-trifluoromethylpyrazol-1-yl]-N-(2,2,2-trifluoroethyl)-2-trifluoromethylbenzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 66.0%

: 753-90-2
trifluoroethylamine

: 1208348-71-3
4-[4-(3,5-dichlorophenyl)-3-trifluoromethylpyrazol-1-yl]-2-trifluoromethylbenzoic acid

: 1208342-05-5
4-[4-(3,5-dichlorophenyl)-3-trifluoromethylpyrazol-1-yl]-N-(2,2,2-trifluoroethyl)-2-trifluoromethylbenzamide

Guidance literature:: With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In N,N-dimethyl-formamide; at 20 ℃; for 8h;

Reference yield:

: ethyl 4-fluoro-2-trifluoromethylbenzoate

: 1208342-05-5
4-[4-(3,5-dichlorophenyl)-3-trifluoromethylpyrazol-1-yl]-N-(2,2,2-trifluoroethyl)-2-trifluoromethylbenzamide

Guidance literature:: Multi-step reaction with 4 steps

1: potassium carbonate / N,N-dimethyl-formamide / 1 h / 60 °C

2: potassium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,2-dimethoxyethane; water / 9 h / 85 °C / Inert atmosphere

3: water; sodium hydroxide / ethanol / 20 °C

4: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 8 h / 20 °C

With water; potassium carbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; sodium hydroxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,2-dimethoxyethane; ethanol; water; N,N-dimethyl-formamide;

Reference yield:

: 1208356-32-4
ethyl 4-(4-iodo-3-trifluoromethylpyrazol-1-yl)-2-trifluoromethylbenzoate

: 1208342-05-5
4-[4-(3,5-dichlorophenyl)-3-trifluoromethylpyrazol-1-yl]-N-(2,2,2-trifluoroethyl)-2-trifluoromethylbenzamide

Guidance literature:: Multi-step reaction with 3 steps

1: potassium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,2-dimethoxyethane; water / 9 h / 85 °C / Inert atmosphere

2: water; sodium hydroxide / ethanol / 20 °C

3: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 8 h / 20 °C

With water; potassium carbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; sodium hydroxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,2-dimethoxyethane; ethanol; water; N,N-dimethyl-formamide;