8-methyl-1,3-diphenyl-5-(4-toluenesulfonyloxy)-pyrido<2,3-d>pyrimidine-2,4,7(1H,3H,8H)-trione

Base Information

• Chemical Name: 8-methyl-1,3-diphenyl-5-(4-toluenesulfonyloxy)-pyrido<2,3-d>pyrimidine-2,4,7(1H,3H,8H)-trione
• CAS No.: 177082-54-1
• Molecular Formula: C₂₇H₂₁N₃O₆S
• Molecular Weight: 515.546

Synonyms:8-methyl-1,3-diphenyl-5-(4-toluenesulfonyloxy)-pyrido<2,3-d>pyrimidine-2,4,7(1H,3H,8H)-trione

Chemical Property of 8-methyl-1,3-diphenyl-5-(4-toluenesulfonyloxy)-pyrido<2,3-d>pyrimidine-2,4,7(1H,3H,8H)-trione

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Technology Process of 8-methyl-1,3-diphenyl-5-(4-toluenesulfonyloxy)-pyrido<2,3-d>pyrimidine-2,4,7(1H,3H,8H)-trione

There total 2 articles about 8-methyl-1,3-diphenyl-5-(4-toluenesulfonyloxy)-pyrido<2,3-d>pyrimidine-2,4,7(1H,3H,8H)-trione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

p-toluenesulfonyl chloride (98-59-9) + 5-hydroxy-8-methyl-1,3-diphenyl-pyrido<2,3-d>pyrimidine-2,4,7-trione (177082-44-9) → 8-methyl-1,3-diphenyl-5-(4-toluenesulfonyloxy)-pyrido<2,3-d>pyrimidine-2,4,7(1H,3H,8H)-trione (177082-54-1)

Guidance literature:

With triethylamine; In acetonitrile; Heating;

DOI:10.1002/prac.19963380129

Reference yield:

6-methylamino-1,3-diphenyl-1H-pyrimidine-2,4-dione (66400-26-8) → 8-methyl-1,3-diphenyl-5-(4-toluenesulfonyloxy)-pyrido<2,3-d>pyrimidine-2,4,7(1H,3H,8H)-trione (177082-54-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 94 percent / diphenyl ether / 2 h / 220 - 250 °C

2: 93 percent / Et₃N / acetonitrile / Heating

With triethylamine; In diphenylether; acetonitrile;

DOI:10.1002/prac.19963380129

Reference yield: 91.0%

p-toluidine (106-49-0,12221-03-3) + 8-methyl-1,3-diphenyl-5-(4-toluenesulfonyloxy)-pyrido<2,3-d>pyrimidine-2,4,7(1H,3H,8H)-trione (177082-54-1) → 8-Methyl-1,3-diphenyl-5-p-tolylamino-1H,8H-pyrido[2,3-d]pyrimidine-2,4,7-trione

Guidance literature:

In isopropyl alcohol; for 12h; Heating;

DOI:10.1002/prac.19963380129

upstream raw materials:

p-toluenesulfonyl chloride

5-hydroxy-8-methyl-1,3-diphenyl-pyrido<2,3-d>pyrimidine-2,4,7-trione

6-methylamino-1,3-diphenyl-1H-pyrimidine-2,4-dione

Downstream raw materials:

8-Methyl-1,3-diphenyl-5-phenylamino-1H,8H-pyrido[2,3-d]pyrimidine-2,4,7-trione

5-(4-Fluoro-phenylamino)-8-methyl-1,3-diphenyl-1H,8H-pyrido[2,3-d]pyrimidine-2,4,7-trione

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