5-methyl-5,7-diphenyl-4,5-dihydro[1,2,4]triazolo[1,5-a]pyrimidine

Base Information

• Chemical Name: 5-methyl-5,7-diphenyl-4,5-dihydro[1,2,4]triazolo[1,5-a]pyrimidine
• CAS No.: 134255-57-5
• Molecular Formula: C₁₈H₁₆N₄
• Molecular Weight: 288.352
• Mol file: 134255-57-5.mol

Synonyms:5-methyl-5,7-diphenyl-4,5-dihydro[1,2,4]triazolo[1,5-a]pyrimidine

Chemical Property of 5-methyl-5,7-diphenyl-4,5-dihydro[1,2,4]triazolo[1,5-a]pyrimidine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 5-methyl-5,7-diphenyl-4,5-dihydro[1,2,4]triazolo[1,5-a]pyrimidine

There total 4 articles about 5-methyl-5,7-diphenyl-4,5-dihydro[1,2,4]triazolo[1,5-a]pyrimidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

acetophenone (98-86-2) + 4H-1,2,4-triazol-3-amine (61-82-5,155-25-9,64598-23-8,65312-61-0,6051-75-8) → 5-methyl-5,7-diphenyl-4,5-dihydro[1,2,4]triazolo[1,5-a]pyrimidine (134255-57-5)

Guidance literature:

With chloro-trimethyl-silane; In N,N-dimethyl-formamide; at 100 ℃; for 8h; regioselective reaction; Sealed tube; Heating;

DOI:10.1002/jhet.972

Reference yield: 50.0%

3(5)-amino-1,2,4-triazole (61-82-5) + acetophenone (98-86-2) → 7-phenyl-1,2,4-triazolo<1,5-a>pyrimidine (39573-72-3) + 5-methyl-5,7-diphenyl-4,5-dihydro[1,2,4]triazolo[1,5-a]pyrimidine (134255-57-5)

Guidance literature:

With acetic acid; In N,N-dimethyl-formamide; for 5h; Heating;

Reference yield:

3(5)-amino-1,2,4-triazole (61-82-5) + N,N-dimethyl-formamide (68-12-2,33513-42-7) + acetophenone (98-86-2) → 7-phenyl-1,2,4-triazolo<1,5-a>pyrimidine (39573-72-3) + 5-methyl-5,7-diphenyl-4,5-dihydro[1,2,4]triazolo[1,5-a]pyrimidine (134255-57-5)

Guidance literature:

With hydrogenchloride; for 5h; Heating;

upstream raw materials:

3⁽⁵⁾-amino-1,2,4-triazole

N,N-dimethyl-formamide

acetophenone

4H-1,2,4-triazol-3-amine