Technology Process of 4-(2-amino-3,5,6,7,8,9-hexahydro-4-oxo-4H-pyrimido<4,5-b>indol-6-yl)benzoic acid
There total 10 articles about 4-(2-amino-3,5,6,7,8,9-hexahydro-4-oxo-4H-pyrimido<4,5-b>indol-6-yl)benzoic acid which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
sodium hydroxide;
In
tetrahydrofuran; water;
for 4h;
Ambient temperature;
DOI:10.3987/com-95-7260
- Guidance literature:
-
Multi-step reaction with 10 steps
1: 1.) n-BuLi / tetrahydrofuran; hexane / 1.) 10 min, -100 deg C; 2.) -95 deg C, 10 min, up to RT
2: 2.5N NaOH / 2-methoxy-ethanol / 100 °C
3: conc. HCl / 4 h / Heating
4: p-toluenesulfonic acid / benzene / 2 h / Heating
5: 90 percent / MsCl, EtN3 / CH2Cl2 / 8 h / 0 °C
6: H2 / 5percent Pd/C / ethanol / 20 h / 2585.7 Torr
7: conc. HCl / ethanol / 4 h / Heating
8: 73 percent / 2-methoxy-ethanol / Heating
9: 91 percent / diphenyl ether / 2.5 h / Heating
10: 82 percent / 1M aq. NaOH / tetrahydrofuran; H2O / 4 h / Ambient temperature
With
hydrogenchloride; sodium hydroxide; n-butyllithium; hydrogen; toluene-4-sulfonic acid; methanesulfonyl chloride; ethyl azide;
palladium on activated charcoal;
In
tetrahydrofuran; diphenylether; ethanol; hexane; dichloromethane; 2-methoxy-ethanol; water; benzene;
DOI:10.3987/com-95-7260
- Guidance literature:
-
Multi-step reaction with 10 steps
1: 1.) n-BuLi / tetrahydrofuran; hexane / 1.) 10 min, -100 deg C; 2.) -95 deg C, 10 min, up to RT
2: 2.5N NaOH / 2-methoxy-ethanol / 100 °C
3: conc. HCl / 4 h / Heating
4: p-toluenesulfonic acid / benzene / 2 h / Heating
5: 90 percent / MsCl, EtN3 / CH2Cl2 / 8 h / 0 °C
6: H2 / 5percent Pd/C / ethanol / 20 h / 2585.7 Torr
7: conc. HCl / ethanol / 4 h / Heating
8: 73 percent / 2-methoxy-ethanol / Heating
9: 91 percent / diphenyl ether / 2.5 h / Heating
10: 82 percent / 1M aq. NaOH / tetrahydrofuran; H2O / 4 h / Ambient temperature
With
hydrogenchloride; sodium hydroxide; n-butyllithium; hydrogen; toluene-4-sulfonic acid; methanesulfonyl chloride; ethyl azide;
palladium on activated charcoal;
In
tetrahydrofuran; diphenylether; ethanol; hexane; dichloromethane; 2-methoxy-ethanol; water; benzene;
DOI:10.3987/com-95-7260
